OLPADRONIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H15NO7P2
Molecular Weight	263.1226
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O

InChI

InChIKey=UGEPSJNLORCRBO-UHFFFAOYSA-N

InChI=1S/C5H15NO7P2/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13)

HIDE SMILES / InChI

Molecular Formula	C5H15NO7P2
Molecular Weight	263.1226
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9567351 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-004269-96/NL | https://www.ncbi.nlm.nih.gov/pubmed/16638872

Olpadronate, a nitrogenated bisphosphonate that can inhibit bone resorption. Although it shares the therapeutic and pharmacological properties of pamidronate and alendronate, it has a greater dosage amplitude, more predictable effects, and greater digestive tolerability than other bisphosphates. Clinical trials have shown that the oral olpadronate was well tolerated and effective in the treatment of Paget's disease. In addition, the drug is ongoing in phase II clinical trials in the Netherlands. This clinical trial has to assess the efficacy of the intravenous drug in decreasing the average back pain intensity from baseline.

Approval Year

PubMed

Title	Date	PubMed
[Treatment of Paget's disease with olpadronate. Its efficacy in partial responders to oral pamidronate].	1997	9567351
Bisphosphonates for Paget's disease of bone in adults.	2017 Dec 1	29192423
Interventions for Improving Bone Mineral Density and Reducing Fracture Risk in Osteogenesis Imperfecta: A Mixed Treatment Comparison Network Meta-analysis of Randomized Controlled Clinical Trials.	2018	30160216

Sample Use Guides

In Vivo Use Guide

Paget's disease: olpadronate was given orally in doses of 100 to 200 mg/day. Initial dose and/or increment of the dose during treatment were decided accordingly to the biochemical response Olpadronate intra venous in chronic low back pain: 20 mg and 40 mg

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:31:39 GMT 2023` Edited by `admin` on `Sat Dec 16 16:31:39 GMT 2023`
Record UNII	874HHB2V3S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OLPADRONIC ACID

Official Name

English

olpadronic acid [INN]

Common Name

English

OLPADRONIC ACID [MART.]

Common Name

English

OLPADRONATE

Common Name

English

(3-(DIMETHYLAMINO)-1-HYDROXYPROPYLIDENE)DIPHOSPHONIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67439