Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H10ClN3O |
| Molecular Weight | 295.723 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C=C1)N2N=C3C(=CNC4=C3C=CC=C4)C2=O
InChI
InChIKey=CQINXWYVIOMBEI-UHFFFAOYSA-N
InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,18H
| Molecular Formula | C16H10ClN3O |
| Molecular Weight | 295.723 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological properties of GABAA receptors containing gamma1 subunits. | 2006-02 |
|
| Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex. | 1988-10 |
|
| Effects of non-sedative anxiolytic drugs on responses to GABA and on diazepam-induced enhancement of these responses on mouse neurones in cell culture. | 1988-09 |
|
| Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models. | 1988 |
|
| Pharmacokinetic disposition of the novel atypical anxiolytic CGS 9896 in the cynomolgus monkey. | 1988 |
|
| CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture. | 1987-07 |
|
| The contribution of behavioural studies to the neuropharmacology of anxiety. | 1987-07 |
|
| Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296. | 1987-05 |
|
| Lack of tolerance or withdrawal effects in mice after chronic administration of the non-sedating anxiolytic, CGS 9896. | 1987-03 |
|
| Behavioral effects of the pyrazoloquinoline CGS 9896: agonist and antagonist actions in squirrel monkeys. | 1987-01 |
|
| Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions. | 1987 |
|
| Are the analgesic effects of social defeat mediated by benzodiazepine receptors? | 1987 |
|
| Partial agonists acting at benzodiazepine receptors can be differentiated in tests of ingestional behaviour. | 1987 |
|
| Anxiolytic action of CGS 9896 on mouse exploratory behavior. | 1986-12-16 |
|
| Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance. | 1986-07 |
|
| CGS 8216, a benzodiazepine antagonist, reduces food intake in food-deprived rats. | 1986-06 |
|
| Simultaneous determination of 2-(p-chlorophenyl)pyrazolo[4,3-c] quinoline-3(5H)-one and its 6-, 7- and 8-hydroxy metabolites in plasma, urine and bile by high-performance liquid chromatography. | 1986-05-28 |
|
| Discriminative stimulus effects of atypical anxiolytics in baboons and rats. | 1986-05 |
|
| Benzodiazepine-induced hyperphagia: stereospecificity and antagonism by pyrazoloquinolines, CGS 9895 and CGS 9896. | 1986 |
|
| Enhancement of GABA binding by the benzodiazepine partial agonist CGS9896. | 1985-12-10 |
|
| CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents. | 1985-10 |
|
| CGS 8216 and CGS 9896, novel pyrazoloquinoline benzodiazepine ligands with benzodiazepine agonist and antagonist properties. | 1985-10 |
|
| The non-sedating anxiolytic CGS 9896 produces discriminative stimuli that may be related to an anxioselective effect. | 1985-08-26 |
|
| Pyrazoloquinoline benzodiazepine receptor ligands: effects on schedule-controlled behavior in dogs. | 1985-08 |
|
| Clonazepam-induced hyperphagia in nondeprived rats: tests of pharmacological specificity with Ro5-4864, Ro5-3663, Ro15-1788 and CGS 9896. | 1985-05 |
|
| Behavioral effects of nonbenzodiazepine anxiolytic drugs: a comparison of CGS 9896 and zopiclone with chlordiazepoxide. | 1985-03 |
|
| Anxiolytic drugs and the acquisition of conditioned fear in mice. | 1985 |
|
| Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor. | 1984-10-30 |
|
| Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896. | 1984-09 |
|
| In vivo determination of efficacy of pyrazoloquinolinones at the benzodiazepine receptor. | 1984-08-03 |
|
| A pharmacokinetic study of CGS-8216, a benzodiazepine receptor ligand, in the rat. | 1984 |
|
| Novel non-benzodiazepine anxiolytics. | 1983-12 |
|
| Antagonism of the discriminative effects of diazepam by pyrazoloquinolines in rats. | 1983-08-19 |
|
| Anxioselective anxiolytics. | 1983-05 |
|
| Benzodiazepine receptor ligands with opposing pharmacologic actions. | 1983 |
|
| A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: characterization of some in vitro and in vivo properties of CGS 9896. | 1982-06-28 |
|
| High affinity inhibition of [3H]-flunitrazepam binding to brain benzodiazepine receptors by CGS 9896, a novel pyrazoloquinoline. | 1982-03-30 |
| Substance Class |
Chemical
Created
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admin
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Edited
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on
Mon Mar 31 17:46:02 GMT 2025
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| Record UNII |
86PWQ4PVN0
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| Record Status |
Validated (UNII)
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| Record Version |
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CGS-9896
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86PWQ4PVN0
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