Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H10ClN3O |
| Molecular Weight | 295.723 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C=C1)N2N=C3C(=CNC4=CC=CC=C34)C2=O
InChI
InChIKey=CQINXWYVIOMBEI-UHFFFAOYSA-N
InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,18H
| Molecular Formula | C16H10ClN3O |
| Molecular Weight | 295.723 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: characterization of some in vitro and in vivo properties of CGS 9896. | 1982 Jun 28 |
|
| High affinity inhibition of [3H]-flunitrazepam binding to brain benzodiazepine receptors by CGS 9896, a novel pyrazoloquinoline. | 1982 Mar 30 |
|
| Antagonism of the discriminative effects of diazepam by pyrazoloquinolines in rats. | 1983 Aug 19 |
|
| Anxioselective anxiolytics. | 1983 May |
|
| Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor. | 1984 Oct 30 |
|
| Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896. | 1984 Sep |
|
| CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents. | 1985 Oct |
|
| Benzodiazepine-induced hyperphagia: stereospecificity and antagonism by pyrazoloquinolines, CGS 9895 and CGS 9896. | 1986 |
|
| Simultaneous determination of 2-(p-chlorophenyl)pyrazolo[4,3-c] quinoline-3(5H)-one and its 6-, 7- and 8-hydroxy metabolites in plasma, urine and bile by high-performance liquid chromatography. | 1986 May 28 |
|
| CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture. | 1987 Jul |
|
| The contribution of behavioural studies to the neuropharmacology of anxiety. | 1987 Jul |
|
| Lack of tolerance or withdrawal effects in mice after chronic administration of the non-sedating anxiolytic, CGS 9896. | 1987 Mar |
|
| Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296. | 1987 May |
|
| Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models. | 1988 |
|
| Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex. | 1988 Oct |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:05:20 UTC 2023
by
admin
on
Fri Dec 15 15:05:20 UTC 2023
|
| Record UNII |
86PWQ4PVN0
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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77779-36-3
Created by
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CGS-9896
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DTXSID20998970
Created by
admin on Fri Dec 15 15:05:20 UTC 2023 , Edited by admin on Fri Dec 15 15:05:20 UTC 2023
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86PWQ4PVN0
Created by
admin on Fri Dec 15 15:05:20 UTC 2023 , Edited by admin on Fri Dec 15 15:05:20 UTC 2023
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PRIMARY |
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