Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H39N.C2H4O2 |
Molecular Weight | 329.5609 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(O)=O.CCCCCCCCCCCCCCCCCCN
InChI
InChIKey=UPHWVVKYDQHTCF-UHFFFAOYSA-N
InChI=1S/C18H39N.C2H4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19;1-2(3)4/h2-19H2,1H3;1H3,(H,3,4)
Molecular Formula | C2H4O2 |
Molecular Weight | 60.052 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C18H39N |
Molecular Weight | 269.509 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Stearamine is an aliphatic amine intended for use in cosmetic formulations as antistatic agent. In cosmetics and personal care products, Lauramine and Stearamine have been used in hair preparations. Stearamine is also used as a corrosion-inhibiting boiler-water additive. Stearamine has antimicrobial properties. Stearylamine has been shown to prevent drug (lansoprazole) degradation and maintained drug stable in nanostructured lipid carriers (NLCs). Stearamine is used as positive charge inducing agent in different pharmaceutical formulations. Thus, the presence of stearylamine reduced the permeability coefficient for the cationic species of the drugs by approximately an order of magnitude, but had no effect on the neutral species of the drugs. The efflux curves observed for both verapamil and prochlorperazine could be mathematically modeled by assuming that the primary influence of stearylamine was on the development of a positive surface charge density on the inner monolayer of the liposome. Taken in sum, these results indicate that stearylamine is effective at decreasing the leakage of cationic drugs from liposomes, and may prove to be a valuable component of liposomal drug formulations.
Approval Year
PubMed
Title | Date | PubMed |
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A new method for the generation of patterned protein films by encapsulation in arrays of thermally evaporated lipids. | 2001 Jul 20 |
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Characterization of calcitonin-containing liposome formulations for intranasal delivery. | 2001 Mar-Apr |
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Characterization of oligonucleotide/lipid interactions in submicron cationic emulsions: influence of the cationic lipid structure and the presence of PEG-lipids. | 2001 Sep 18 |
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Langmuir-Blodgett films of a clay mineral and ruthenium(II) complexes with a noncentrosymmetric structure. | 2002 Feb 13 |
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Stability and release of topical tranexamic acid liposome formulations. | 2002 Nov-Dec |
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[Protective and rescue effects of transgenic bFGF/GFP expression mediated by cationic liposome on gentamicin-induced guinea pig cochlear toxicity]. | 2002 Sep 10 |
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Preparation of porous cobalt and nickel oxides from corresponding alkoxides using a sonochemical technique and its application as a catalyst in the oxidation of hydrocarbons. | 2003 Jan |
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Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats. | 2003 Jan 17 |
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Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X. | 2003 Mar 14 |
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Candida bombicola cells immobilized on patterned lipid films as enzyme sources for the transformation of arachidonic acid to 20-HETE. | 2003 Nov-Dec |
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Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layer. | 2003 Oct 17 |
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Liposomal amikacin dry powder inhaler: effect of fines on in vitro performance. | 2004 Aug 9 |
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Preparation of microcapsules containing two-phase core materials. | 2004 Dec 7 |
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Molecular transfer and transport in noncovalent microcontact printing. | 2004 Feb 3 |
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Synthesis and evaluation of a hematoporphyrin derivative in a folate receptor-targeted solid-lipid nanoparticle formulation. | 2004 Jan-Feb |
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Influence of ammonium nitrate in phase transitions of Langmuir and Langmuir-Blodgett films at air/solution and solid/solution interfaces. | 2004 Jul 1 |
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Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. | 2004 Mar 24 |
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Determination of aliphatic amines in mineral flotation liquors and reagents by high-performance liquid chromatography after derivatization with 4-chloro-7-nitrobenzofurazan. | 2004 Nov 5 |
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Immobilization of Candida bombicola cells on free-standing organic-gold nanoparticle membranes and their use as enzyme sources in biotransformations. | 2004 Nov-Dec |
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Keggin ion mediated synthesis of hydrophobized Pd nanoparticles for multifunctional catalysis. | 2005 Mar 15 |
Patents
Sample Use Guides
In a subchronic feeding study in rats, 3,000 ppm of Stearamine in the diet caused weight loss and increased mortality, with an accumulation of his- tiocytes in the mucosa of the small intestine and mesenteric lymph nodes. A diet of 500 ppm did not produce these effects. Dogs fed Stearamine at 15 mg/kg/day showed the same histiocyte accumulation. In a 2-year chronic feed- ing study in rats, Stearamine at concentrations up to 500 ppm (maximum tested) showed no significant increase in the incidence of tumors.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:19:28 GMT 2023
by
admin
on
Sat Dec 16 08:19:28 GMT 2023
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Record UNII |
856J14021A
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Record Status |
Validated (UNII)
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Record Version |
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