HEXETIDINE

US Previously Marketed

First approved in 1956

Details

Stereochemistry	MIXED
Molecular Formula	C21H45N3
Molecular Weight	339.6021
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1

InChI

InChIKey=DTOUUUZOYKYHEP-UHFFFAOYSA-N

InChI=1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C21H45N3
Molecular Weight	339.6021
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11917691

Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient. These characteristics give important therapeutic role in treatment of oral infections. In the UK, hexetidine is the active ingredient in the medicated mouthwash branded Oraldene. Oraldene contains 0.1 g/100 ml of hexetidine. In Germany, hexetidine is used for vaginal antisepsis.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Mouth ulcers 8 Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html	Curative	Approved 8429	Oraldene Approved Use Unknown
Gingivitis 44 Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html	Curative	Approved 8429	Oraldene Approved Use Unknown
Oral thrush 5 Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html	Curative	Approved 8429	Oraldene Approved Use Unknown

Doses

Dose	Population	Adverse events
0.1 % 1 times / day multiple, oromucosal Dose: 0.1 %, 1 times / day Route: oromucosal Route: multiple Dose: 0.1 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/12834495	unhealthy, 38.2 years (range: 18–61 years) n = 46 Health Status: unhealthy Condition: supragingival plaque \| gingivitis Age Group: 38.2 years (range: 18–61 years) Sex: M+F Population Size: 46 Sources: https://pubmed.ncbi.nlm.nih.gov/12834495	Sources: https://pubmed.ncbi.nlm.nih.gov/12834495
10 mg 1 times / day multiple, vaginal Dose: 10 mg, 1 times / day Route: vaginal Route: multiple Dose: 10 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/1773929	unhealthy n = 100 Health Status: unhealthy Sex: F Population Size: 100 Sources: https://pubmed.ncbi.nlm.nih.gov/1773929	Sources: https://pubmed.ncbi.nlm.nih.gov/1773929

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY522065	https://www.001chemical.com/chem/141-94-6
3B Scientific (Wuhan) Corp	3B3-023208	http://www.3bsc.com/index/pro_info.php?id=44285
AA Blocks	AA003QUE	https://www.aablocks.com/goods/Goods/detail?id=AA003QUE
AEchem Scientific Corp., USA	AE059285	https://www.aechemsc.com/info2_products/AE059285.php
AHH Chemical co.,ltd	MT-14721	http://www.ahhchemical.com/product/MT-14721.html
AK Scientific, Inc. (AKSCI)	X6883	http://www.aksci.com/item_detail.php?cat=X6883
Aaron Chemicals	AR003RM6	http://www.aaronchem.com/141-94-6
AbMole Bioscience	M5010	http://www.abmole.com/products/hexetidine.html
Alfa Aesar	L18699	https://www.alfa.com/en/catalog/L18699/
Ambeed	A560776	https://www.ambeed.com/products/141-94-6.html
BLD Pharm	BD133334	http://www.bldpharm.com/products/141-94-6.html
CSNpharm	CSN11149	https://www.csnpharm.com/products/hexetidine.html
Chem Scene	CS-4490	http://www.chemscene.com/141-94-6.html
ChemMol	49426750	http://www.chemmol.com/chemmol/49426750.html
Chemspace	CSSB00000039703	https://chem-space.com/CSSB00000039703
Clearsynth	CS-L-00161	https://www.clearsynth.com/en/CSL00161.html
DC Chemicals	DC37311	http://www.dcchemicals.com//product_show-Hexetidine.html
Debye Scientific	DB-042594	http://www.debyesci.com/cas_141-94-6.html
Finetech	FT-0627047	http://www.finetechnology-ind.com/prod/detail/pub/141-94-6.html
Hairui	HR123325	http://www.hairuichem.com/en/product/141-94-6.html
LGC Standards	DRE-A14202900AL-100	https://www.lgcstandards.com/US/en/p/DRE-A14202900AL-100
LGC Standards	DRE-C14202900	https://www.lgcstandards.com/US/en/p/DRE-C14202900
LGC Standards	MM0337.00	https://www.lgcstandards.com/US/en/p/MM0337.00
Lab Network	LN00241642	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00241642
MedChem Express	HY-B0996	https://www.medchemexpress.com/Hexetidine.html
Molcore	MC522065	https://www.molcore.com/product/141-94-6
MuseChem	I001610	https://www.musechem.com/product/I001610.html
OChem	7723	http://www.ocheminc.com/index.php?act=psearch&pid=141H946
Parchem	29099	http://www.parchem.com/chemical-supplier-distributor/Hexetidine-019099.aspx
Sigma-Aldrich	259187_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/259187?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	H0325000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/h0325000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S529914	http://www.smolecule.com/products/s529914
THE BioTek	bt-270805	https://www.thebiotek.com/product/inhibitors/bt-270805
abcr GmbH	AB180540	http://www.abcr.com/shop/en/AB180540
iChemical	EBD33094	http://www.ichemical.com/products/141-94-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-8471986715	https://mcule.com/MCULE-8471986715/

PubMed

Title	Date	PubMed
[Analytical profile of purified hexetidine (author's transl)].	1975	3183
[Disturbances of taste from oral disinfectants (author's transl)].	1978 Oct	711516
The erosive effects of some mouthrinses on enamel. A study in situ.	2001 Apr	11314887
The concomitant development of poly(vinyl chloride)-related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia.	2001 Oct	11545308
A comparative study in vivo of the therapeutic effect of triclosan, hexetidine and chitosan.	2002	15208937
[Hexetidine--an oral antiseptic].	2002	11917691
Nonaqueous capillary electrophoretic analysis of hexetidine in a commercial liquid formulation.	2002 Apr	11998443
Physicochemical characterization of hexetidine-impregnated endotracheal tube poly(vinyl chloride) and resistance to adherence of respiratory bacterial pathogens.	2002 Jun	12134952
An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses.	2002 Mar-Apr	12037365
Antimicrobial action of Nitens mouthwash (cetyltrimethylammonium naproxenate) on multiple isolates of pharyngeal microbes: a controlled study against chlorhexidine, benzydamine, hexetidine, amoxicillin, amoxicillin-clavulanate, clarithromycin, and cefaclor.	2002 Sep	12218263
Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash.	2003 Jul	12834495
Clinical study on the effectiveness and side effects of hexetidine and chlorhexidine mouthrinses versus a negative control.	2005 Sep	16161468
Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis.	2005 Sep	16120118
[Stopangin in the treatment of pharyngeal inflammation].	2006	17152477
Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis.	2006 Jul	16792733
Mucocutaneous lesions of Behcet's disease.	2007 Aug 31	17722228
[Efficacy of an antiseptic dialysis of purulent wounds in the dentofacial region with hyvalix].	2007 Jul-Sep	18416174
[Combined local therapy in oropharyngeal diseases].	2008	18454082
Efficacy of vaginal misoprostol before hysteroscopy for cervical priming in patients who have undergone cesarean section and no vaginal deliveries.	2008 Jul-Aug	18588848
Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.	2009 Sep 23	19774075
Parotid gland swelling following mouthrinse use.	2010 Nov	20961383
The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model - a cross-over study.	2010 Nov	20961382
The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review.	2011 Aug	21356020

Patents

Sample Use Guides

In Vivo Use Guide

mouthwash

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:19:20 GMT 2023` Edited by `admin` on `Sat Dec 16 17:19:20 GMT 2023`
Record UNII	852A84Y8LS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXETIDINE

Official Name

English

HEXETIDINE [MART.]

Common Name

English

HEXETIDINE [INCI]

Common Name

English

STERISIL

Brand Name

English

HEXETIDINE [EP MONOGRAPH]

Common Name

English

NSC-17764

Code

English

HEXETIDINE [HSDB]

Common Name

English

Hexetidine [WHO-DD]

Common Name

English

hexetidine [INN]

Common Name

English

HEXETIDINE [MI]

Common Name

English

5-AMINO-1,3-BIS(2-ETHYLHEXYL)HEXAHYDRO-5-METHYLPYRIMIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394