ACREOZAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14ClN3O6
Molecular Weight	367.741
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)OCC(=O)NC1=CC(=CC(NC(=O)COC(C)=O)=C1Cl)C#N

InChI

InChIKey=VNVBCWREJHKWSG-UHFFFAOYSA-N

InChI=1S/C15H14ClN3O6/c1-8(20)24-6-13(22)18-11-3-10(5-17)4-12(15(11)16)19-14(23)7-25-9(2)21/h3-4H,6-7H2,1-2H3,(H,18,22)(H,19,23)

HIDE SMILES / InChI

Molecular Formula	C15H14ClN3O6
Molecular Weight	367.741
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.chemdrug.com/article/8/3285/16420469.html

Acreozast is an orally active antiallergic agent, which has anti-inflammatory activity. It was undergoing phase II clinical trials in Japan for the following condition: Asthma and Atopic dermatitis. Toyobo discontinued the development of acreozast in 1996.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Atopic dermatitis 43 Sources: http://www.chemdrug.com/article/8/3285/16420469.html	Primary		Phase II 1132	Unknown Approved Use Unknown
Asthma 241 Sources: http://www.chemdrug.com/article/8/3285/16420469.html	Primary		Phase II 1132	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effect of TYB-2285 on histamine release from human basophils in the presence/absence of IL-3.	1993 Mar	7683300

Patents

Sample Use Guides

In Vivo Use Guide

rats: 3-30 mg/kg

Route of Administration: Oral

In Vitro Use Guide

Histamine release was enhanced by the pretreatment of basophils with recombinant interleukin 3 (rIL-3) (0.3-10 U/ml) in 18 out of 22 subjects. Histamine release in the presence of rIL-3 was inhibited by TYB-2285 (ACREOZAST) in a dose-dependent manner (1-100 microM). Histamine release in the absence of rIL-3 was not inhibited by TYB-2285 at concentrations less than 1 mM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:09 GMT 2023`
Record UNII	84DZ9RW4WK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACREOZAST

Official Name

English

acreozast [INN]

Common Name

English

N,N'-(2-CHLORO-5-CYANO-M-PHENYLENE)BIS(GLYCOLAMIDE)DIACETATE (ESTER)

Common Name

English

ADEOZAST [JAN]

Common Name

English

ADEOZAST

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29712