Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C19H20ClNO2 |
Molecular Weight | 329.821 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCC2=C(C=C(O)C(Cl)=C2)[C@H](C1)C3=C4OCCC4=CC=C3
InChI
InChIKey=SKMVRXPBCSTNKE-MRXNPFEDSA-N
InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3/t16-/m1/s1
Molecular Formula | C19H20ClNO2 |
Molecular Weight | 329.821 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/1352206Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/10231129
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1352206
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/10231129
Odapipam is a benzazepine with high affinity and selectivity for D1-dopamine receptors. Labeled with C-11, it has been used as a PET radiotracer to visualize D1 receptors both in striatal and extrastriatal areas, such as the prefrontal cortex. Odapipam inhibits dopamine D1 receptor binding in vitro with low nanomolar to picomolar dissociation constants. The affinity of [11C]NNC 756 for D1 receptors is 0.18 nM. Odapipam was tested in phase I of clinical trials for the treatment of psychotic disorders, but failed.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2056 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7855175 |
0.18 nM [Kd] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7675940
The drug is given as a single oral dose of 80 mg.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:26:24 GMT 2025
by
admin
on
Mon Mar 31 18:26:24 GMT 2025
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Record UNII |
847PQF7ZN6
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C66883
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131796-63-9
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7014
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132421
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100000083310
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C90842
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SUB09421MIG
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C075357
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CHEMBL2106649
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Related Record | Type | Details | ||
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LABELED -> NON-LABELED | |||
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TARGET -> INHIBITOR |
IC50
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Related Record | Type | Details | ||
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ACTIVE MOIETY |