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Details

Stereochemistry ACHIRAL
Molecular Formula C7H3F12N3
Molecular Weight 357.0997
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MIDAFLUR

SMILES

NC1=NC(NC1(C(F)(F)F)C(F)(F)F)(C(F)(F)F)C(F)(F)F

InChI

InChIKey=KYWMWUUMCDZISK-UHFFFAOYSA-N
InChI=1S/C7H3F12N3/c8-4(9,10)2(5(11,12)13)1(20)21-3(22-2,6(14,15)16)7(17,18)19/h22H,(H2,20,21)

HIDE SMILES / InChI

Molecular Formula C7H3F12N3
Molecular Weight 357.0997
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Midaflur, an imidazoline derivative, was developed as an anesthetic agent. This drug acted as a central skeletal muscle relaxant and showed sedative properties. Preclinical experiments have shown that midaflur had minimal effects at high doses in cardiovascular studies. In addition, it was inactive in anti-inflammatory, diuretic, and plasma glucose studies. Information about the current use of this compound is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
The pharmacology and toxicology of midaflur.
1971 Apr
Quantitative electroencephalographic and metabolic studies of midaflur, a new anesthetic agent.
1979 Aug
[Central sites for the muscle relaxation activity of midaflur (author's transl)].
1980 Dec
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:24:52 GMT 2023
Edited
by admin
on Fri Dec 15 15:24:52 GMT 2023
Record UNII
840CTL676L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MIDAFLUR
INN   USAN  
INN   USAN  
Official Name English
4-Amino-2,2,5,5-tetrakis(trifluoromethyl)-3-imidazoline
Systematic Name English
EXP 338
Code English
1H-IMIDAZOL-4-AMINE, 2,5-DIHYDRO-2,2,5,5-TETRAKIS(TRIFLUOROMETHYL)-
Systematic Name English
EXP-338
Code English
MIDAFLUR [USAN]
Common Name English
midaflur [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29756
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
Code System Code Type Description
CAS
23757-42-8
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
MESH
C022154
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
FDA UNII
840CTL676L
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
WIKIPEDIA
Midaflur
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
EPA CompTox
DTXSID50178425
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104707
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
PUBCHEM
32068
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
INN
2613
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
SMS_ID
100000080624
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
EVMPD
SUB08946MIG
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
NCI_THESAURUS
C90942
Created by admin on Fri Dec 15 15:24:52 GMT 2023 , Edited by admin on Fri Dec 15 15:24:52 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY