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Details

Stereochemistry ACHIRAL
Molecular Formula C23H24Cl2N4O2
Molecular Weight 459.368
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIDA-41020

SMILES

COC1=CC=C(C=C1)C2=C(C)C(=NN2C3=CC=C(Cl)C=C3Cl)C(=O)NN4CCCCC4

InChI

InChIKey=KWDBQJRWPWTGPF-UHFFFAOYSA-N
InChI=1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)

HIDE SMILES / InChI
Molecular Formula C23H24Cl2N4O2
Molecular Weight 459.368
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

NIDA-41020 is a functional CB1 cannabinoid receptor antagonist.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 4.1 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.
2003 Feb 13
Patents

Patents

US8063062
1
US8138174
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: Pretreatment of the slices from the nucleus accumbens of rat brain with NIDA-41020 blocked the ability of the cannabinoid receptor agonist WIN 55,212-2 to reduce the field potentials, but had no effect on the baseline (pretreatment) synaptic responses
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:59:25 GMT 2023
Edited
by admin
on Sat Dec 16 08:59:25 GMT 2023
Record UNII
83E62L67ID
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NIDA-41020
Common Name English
1H-PYRAZOLE-3-CARBOXAMIDE, 1-(2,4-DICHLOROPHENYL)-5-(4-METHOXYPHENYL)-4-METHYL-N-1-PIPERIDINYL-
Systematic Name English
Code System Code Type Description
PUBCHEM
11037861
Created by admin on Sat Dec 16 08:59:25 GMT 2023 , Edited by admin on Sat Dec 16 08:59:25 GMT 2023
PRIMARY
FDA UNII
83E62L67ID
Created by admin on Sat Dec 16 08:59:25 GMT 2023 , Edited by admin on Sat Dec 16 08:59:25 GMT 2023
PRIMARY
CAS
502486-89-7
Created by admin on Sat Dec 16 08:59:25 GMT 2023 , Edited by admin on Sat Dec 16 08:59:25 GMT 2023
PRIMARY
EPA CompTox
DTXSID00452843
Created by admin on Sat Dec 16 08:59:25 GMT 2023 , Edited by admin on Sat Dec 16 08:59:25 GMT 2023
PRIMARY
Related Record Type Details
Structure of NIDA-41020
ACTIVE MOIETY
NIH
NCATS
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