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Details

Stereochemistry ACHIRAL
Molecular Formula C11H15N3O4
Molecular Weight 253.2545
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRICARBATE

SMILES

CNC(=O)OCC1=CC=CC(COC(=O)NC)=N1

InChI

InChIKey=YEKQSSHBERGOJK-UHFFFAOYSA-N
InChI=1S/C11H15N3O4/c1-12-10(15)17-6-8-4-3-5-9(14-8)7-18-11(16)13-2/h3-5H,6-7H2,1-2H3,(H,12,15)(H,13,16)

HIDE SMILES / InChI

Molecular Formula C11H15N3O4
Molecular Weight 253.2545
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/213636

Parmidin (pyridinol carbamate) is a Soviet drug, has anti-arteriosclerotic (increased vascular resistance) activity, reduces the permeability of blood vessels, it helps to restore disturbed microcirculation in pathological processes. This is mainly due to the influence on kinin system, especially with a decrease in the activity of bradykinin receptors. It also reduces the aggregation of platelets. It’s used to treat: the brain vascular atherosclerosis, heart, limbs; diabetic retinopathy (non-inflammatory lesion of the retina associated with increased levels of sugar in the blood); thrombosis (violation of patency) retinal vein; occlusive disease (inflammation of the inner lining of arteries with a decrease in their lumen); trophic leg ulcers (slow-healing skin defects caused by malnutrition). Ointment is used in neurodermatitis (skin disease caused by disturbance of the central nervous system), Lichen sclerosus (teardrop scleroderma) genital organs of children, as well as a prophylactic and therapeutic agent against radiation skin lesions.

Originator

Sources: Ochanomizu Igaku Zasshi (1965), 13, (3), 185-7.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL4308
Sources: DOI: 10.1007/BF00776332 Tugusheva, N.Z., Ershov, L.V., Granik, V.G. et al. Pharm Chem J (1986) 20: 483. doi:10.1007/BF00776332
Target ID: CHEMBL3157
Sources: DOI: 10.1007/BF00776332 Tugusheva, N.Z., Ershov, L.V., Granik, V.G. et al. Pharm Chem J (1986) 20: 483. doi:10.1007/BF00776332
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Parmidin tablets 0,25 g

Approved Use

Atherosclerosis of vessels of the brain, heart, limbs, eyes (comprehensive treatment and prevention).
Palliative
Parmidin

Approved Use

Unknown
Palliative
Parmidin

Approved Use

Unknown
Palliative
Parmidin

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Lipid synthesis in normal and atherosclerotic human intima in vitro under the effect of pyridinolcarbamate].
1976
Effects of phthalazinol (EG 626) and pyridinolcarbamate (Anginin) on lipolytic enzyme activities in rat adipose tissue -in vivo and in vitro-.
1980 Feb
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: http://www.piluli.kharkov.ua/drugs/drug/531/
Oral: 0.25-0.75 g 3-4 times/day. The course: 2-6 months. Topical:- 2-3 times a day for 10-12 days
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:32:17 GMT 2023
Edited
by admin
on Fri Dec 15 17:32:17 GMT 2023
Record UNII
81R511UV73
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PYRICARBATE
INCI   INN   MART.   WHO-DD  
INCI   INN  
Official Name English
COLESTERINEX
Brand Name English
CICLOVEN
Brand Name English
PYRICARBATE [MART.]
Common Name English
ATEROSAN
Brand Name English
PYRIDINOLCARBAMATE
Common Name English
H-3749
Code English
SOSPITAN
Brand Name English
2,6-PYRIDINEDIMETHANOL BIS(METHYLCARBAMATE) (ESTER)
Common Name English
PYRIDINOL CARBAMATE [JAN]
Common Name English
2,6-PYRIDINEDIYLDIMETHYLENE BIS(METHYLCARBAMATE)
Systematic Name English
PYRIDINOL CARBAMATE [MI]
Common Name English
MOVECIL
Brand Name English
VASOVERIN
Brand Name English
2,6-PYRIDINYLENEBIS(METHYL-N-METHYLCARBAMATE)
Common Name English
RAVENIL
Brand Name English
ANGIOXINE
Brand Name English
VASOCIL
Brand Name English
ANGININ
Brand Name English
pyricarbate [INN]
Common Name English
PYRICARBATE [INCI]
Common Name English
DUVALINE
Brand Name English
ATOVER
Brand Name English
PRODECTIN
Brand Name English
PYRIDINOL CARBAMATE
JAN   MI  
Systematic Name English
Pyricarbate [WHO-DD]
Common Name English
VASAGIN
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C29703
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
Code System Code Type Description
EVMPD
SUB10164MIG
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
INN
5011
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
NCI_THESAURUS
C152114
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
SMS_ID
100000080866
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
ECHA (EC/EINECS)
217-538-9
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
PUBCHEM
4990
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
ChEMBL
CHEMBL1620144
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
MESH
D011727
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
MERCK INDEX
m9358
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID5045708
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
DRUG CENTRAL
2329
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
FDA UNII
81R511UV73
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
CAS
1882-26-4
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY
RXCUI
8997
Created by admin on Fri Dec 15 17:32:17 GMT 2023 , Edited by admin on Fri Dec 15 17:32:17 GMT 2023
PRIMARY RxNorm
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ACTIVE MOIETY