TRIFLUBAZAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H13F3N2O2
Molecular Weight	334.2925
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(C=C(C=C2)C(F)(F)F)N(C3=CC=CC=C3)C(=O)CC1=O

InChI

InChIKey=DMNPCIKBNDKNTO-UHFFFAOYSA-N

InChI=1S/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H13F3N2O2
Molecular Weight	334.2925
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20917 | https://www.ncbi.nlm.nih.gov/pubmed/11024 | https://www.ncbi.nlm.nih.gov/pubmed/241616

Triflubazam is a 1,5-benzodiazepine derivative. The hypnotic activity of the 1,5-benzodiazepines is limited, and that this is particularly so in the case of triflubazam. Subjects reported impaired sleep with triflubazam (40 mg), and a sense of less wakefulness the morning. The effect of triflubazam may have persisted beyond the night of ingestion. No effect of triflubazam was observed on total sleep time, stage shifts in the first 6 h or latency to the first rapid eye movement period of sleep. Triflubazam has psychopharmacological properties in animals suggestive of antianxiety activity of a longer duration than that of diazepam. The metabolism of triflubazam by man is characterized by extensive N-demethylation, aromatic hydroxylation, aromatic O-methylation and dihydrodiol formation.

Approval Year

PubMed

Title	Date	PubMed
Proceedings: Blood level, excretion, distribution and metabolism of 14C-triflubazam, a new 1,5-benzodiazepine, in mice and dogs.	1974	4276517
Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.	1974 Sep	4154182
High-pressure liquid chromatographic analysis of triflubazam and its metabolites in human and animal blood and urine.	1975 Aug	239208
Comparative biotransformation of triflubazam in rats, dogs, and monkeys.	1975 Nov-Dec	1219
Biotransformation of a 1,5-benzodiazepine, triflubazam, by man.	1975 Sep-Oct	241616
Controlled clinical and quantitative EEG studies of triflubazam (ORF 8063) in patients with anxiety syndrome.	1976 Mar	5248
Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on the sleep of man [proceedings].	1976 Nov	11024
Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man.	1977 Oct	20917
A novel one-pot three-(in situ five-)component condensation reaction: an unexpected approach for the synthesis of tetrahydro-2,4-dioxo-1H-benzo[b][1,5]diazepine-3-yl-2-methylpropanamide derivatives.	2009 Aug 6	19719182

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:32:20 UTC 2023` Edited by `admin` on `Fri Dec 15 18:32:20 UTC 2023`
Record UNII	80D8H0388T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIFLUBAZAM

Official Name

English

1H-1,5-BENZODIAZEPINE-2,4(3H,5H)-DIONE, 1-METHYL-5-PHENYL-7-(TRIFLUOROMETHYL)-

Systematic Name

English

WE-352

Code

English

TRIFLUBAZAM [USAN]

Common Name

English

ORF-8063

Code

English

triflubazam [INN]

Common Name

English

WE352

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29756