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Details

Stereochemistry ACHIRAL
Molecular Formula F6Si.2Na
Molecular Weight 188.0555
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM HEXAFLUOROSILICATE

SMILES

[Na+].[Na+].F[Si--](F)(F)(F)(F)F

InChI

InChIKey=TWGUZEUZLCYTCG-UHFFFAOYSA-N
InChI=1S/F6Si.2Na/c1-7(2,3,4,5)6;;/q-2;2*+1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula F6Si
Molecular Weight 142.0759
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ammonium hexafluorosilicate is a white crystalline solid. Corrodes aluminum. Used as a disinfectant, in etching glass, metal casting, and electroplating. Ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity, since ammonium hexafluorosilicate induced calcium phosphate precipitation from the saliva; therefore, it has a continuous effect on dentin tubules occlusion under a simulated oral environment. Ammonium hexafluorosilicate has been applied to arrest caries without discoloration. The major use of sodium hexafluorosilicate and fluorosilicic acid is as fluoridation agents for drinking water. Sodium hexafluorosilicate has also been used for caries control as part of asilicophosphate cement, an acidic gel in combination with monocalcium phosphate monohydrate,and a two-solution fluoride mouth rinse. Both chemicals are also used as a chemical intermediate (raw material) for aluminum trifluoride, cryolite (Na3AlF6), silicon tetrafluoride,and other fluorosilicates and have found applications in commercial laundry. Other applications for sodium hexafluorosilicate include its use in enamels/enamel frits for china and porcelain, in opalescent glass, metallurgy (aluminum and beryllium), glue, ore flotation, leather and wood preservatives, and in insecticides and rodenticides. It has been used in the manufacture of pure silicon, as a gelling agent in the production of molded latex foam, and as afluorinating agent in organic synthesis to convert organodichlorophosphorus compounds to the corresponding organodifluorophosphorus compound. In veterinary practice, external applicationof sodium hexafluorosilicate combats lice and mosquitoes on cattle, sheep, swine, and poultry, and oral administration combats roundworms and possibly whipworms in swine and prevents dental caries in rats. Apparently, all pesticidal products had their registrations cancelled or they were discontinued by the early 1990s

Approval Year

PubMed

PubMed

TitleDatePubMed
Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion.
2008 Feb
Cytotoxicity of ammonium hexafluorosilicate on human gingival fibroblasts.
2013 Dec
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: In mice, an oral LD50 of 70 mg/kg (0.37 mmol/kg) for sodium hexafluorosilicate was reported. In rats, oral LD50 values of 125 and 430 mg/kg (0.665 and 2.29 mmol/kg, respectively) were calculated.
A probable oral lethal dose of 50-5000 mg/kg, classified as very toxic, has been reported for doses between 1 teaspoon and 1 ounce for a 150-pound (70-kg) person; a probable oral lethal dose of 5-50 mg/kg, classified as extremely toxic, has been reported for doses between 7 drops and 1 teaspoon for the same individual.
Route of Administration: Oral
The purpose of the study was to investigate the cytotoxicity of Ammonium hexafluorosilicate (SiF) on human gingival fibroblasts (hGFs) under different dosages (0.001%, 0.01%, 0.1%, and 1%) and treatment durations (1, 5, 10, and 30 min). MTT assay showed that there was significantly lower number of viable cells when the hGFs were treated with 0.01% (10min), 0.1% (10 and 30 min) and 1% (5, 10, and 30min) SiF than the control group (p<0.05). MMP decreased and GSH depletion increased dramatically along with higher concentrations (0.1% and 1% SiF) and prolonged times (10 and 30 min). DNA synthesis [S (%)] of cells treated with 0.1% and 1% SiF (5, 10, and 30min) was significantly lower than the control group (p<0.05). So exposure to up to 0.01% SiF for less than 5min causes low or no cytotoxicity in vitro.
Substance Class Chemical
Created
by admin
on Sat Dec 16 20:13:36 GMT 2023
Edited
by admin
on Sat Dec 16 20:13:36 GMT 2023
Record UNII
806AV2E065
Record Status Validated (UNII)
Record Version
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Name Type Language
SODIUM HEXAFLUOROSILICATE
HSDB   ISO   MI  
Common Name English
SODIUM HEXAFLUOROSILICATE [MI]
Common Name English
SILICATE(2-), HEXAFLUORO-, SODIUM (1:2)
Common Name English
NATRUM SILICOFLUORICUM
HPUS  
Common Name English
SODIUM HEXAFLUOROSILICATE [ISO]
Common Name English
SODIUM HEXAFLUOROSILICATE [HSDB]
Common Name English
SODIUM FLUOROSILICATE [INCI]
Common Name English
SODIUM FLUOROSILICATE
INCI  
INCI  
Official Name English
SODIUM SILICOFLUORIDE
MART.  
Common Name English
NATRUM SILICOFLUORICUM [HPUS]
Common Name English
SODIUM SILICON FLUORIDE (NA2SIF6)
Common Name English
SODIUM SILICOFLUORIDE [MART.]
Common Name English
SODIUM FLUOSILICATE
Common Name English
DISODIUM HEXAFLUOROSILICATE (NA2SIF6)
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 75306
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
Code System Code Type Description
PUBCHEM
28127
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
EPA CompTox
DTXSID9036933
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
FDA UNII
806AV2E065
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
ALANWOOD
sodium silicofluoride
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
CAS
16893-85-9
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
MERCK INDEX
m10029
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
240-934-8
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
HSDB
770
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
MESH
C557271
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
RXCUI
1862868
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
WIKIPEDIA
Sodium fluorosilicate
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
DAILYMED
806AV2E065
Created by admin on Sat Dec 16 20:13:36 GMT 2023 , Edited by admin on Sat Dec 16 20:13:36 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE