TROPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H15NO
Molecular Weight	141.2108
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1[C@H]2CC[C@@H]1C[C@H](O)C2

InChI

InChIKey=CYHOMWAPJJPNMW-JIGDXULJSA-N

InChI=1S/C8H15NO/c1-9-6-2-3-7(9)5-8(10)4-6/h6-8,10H,2-5H2,1H3/t6-,7+,8+

HIDE SMILES / InChI

Molecular Formula	C8H15NO
Molecular Weight	141.2108
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13247221 | https://www.ncbi.nlm.nih.gov/pubmed/10387002 | https://www.ncbi.nlm.nih.gov/pubmed/3337019

Tropine is a naturally-occurring tropane alkaloid, which can be obtained from tropinone under the action of Tropinone reductases I. Tropine serves as an intermediate in the synthesis of different bioactive alkaloids, including atropine. In 1950th was published an article, where was described the use tropine in the treatment of angina pectoris. But in further articles were mentioned the derivative of tropine, atropine for the treatment of this disease.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Angina pectoris 110 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13247221	Primary		Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Treatment of Cushing disease: overview and recent findings.	2010-10-21	21063461
The functional divergence of short-chain dehydrogenases involved in tropinone reduction.	2008-05	18221363
Quaternary derivatives of granatanol diesters: potent, ultrashort acting non-depolarizing neuromuscular relaxants.	2006-07-04	16516930
Calystegines in wild and cultivated Erythroxylum species.	2005-06	15907958
Structure-activity relationships among derivatives of dicarboxylic acid esters of tropine.	2002-10	12441175
Neuromuscular pharmacology of TAAC3, a new nondepolarizing muscle relaxant with rapid onset and ultrashort duration of action.	2002-04	11916790
The new neuromuscular blocking agents: do they offer any advantages?	2001-12	11878696
Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.	1999-08-26	10464017

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:27:48 GMT 2025` Edited by `admin` on `Mon Mar 31 21:27:48 GMT 2025`
Record UNII	7YXR19M72Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

A-804485

Preferred Name

English

TROPINE

Common Name

English

TROPINE [EP IMPURITY]

Common Name

English

TROPINE [MI]

Common Name

English

8-AZABICYCLO(3.2.1)OCTAN-3-OL, 8-METHYL-, (3-ENDO)-

Common Name

English

TROPANOL

Systematic Name

English

1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL

Common Name

English

TROPISETRON HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

2,3-DIHYDRO-3.ALPHA.-HYDROXYTROPIDINE

Common Name

English

3.ALPHA.-TROPANOL

Common Name

English

8-AZABICYCLO(3.2.1)OCTAN-3-OL, 8-METHYL-, ENDO-

Common Name

English

.ALPHA.-TROPINE

Common Name

English

NSC-43870

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29704