TRELOXINATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12Cl2O4
Molecular Weight	339.17
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C1OC2=CC=C(Cl)C=C2CC3=CC(Cl)=CC=C3O1

InChI

InChIKey=BORQIQWYKSNHKN-UHFFFAOYSA-N

InChI=1S/C16H12Cl2O4/c1-20-15(19)16-21-13-4-2-11(17)7-9(13)6-10-8-12(18)3-5-14(10)22-16/h2-5,7-8,16H,6H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H12Cl2O4
Molecular Weight	339.17
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4635973 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1225, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | Bencze, W.L. et al. (2012) Hypolipidemic Agents, page 389, retrieved from: https://books.google.ru/books?id=a1bmCAAAQBAJ

Treloxinate is a potent hypolipidemic agent. Treloxinate and its acid are structurally related to clofibrate. The activities of treloxinate and its acid form have been found to be identical. In rats treloxinate is 8 times as potent as clofibrate in reducing plasma cholesterol levels and 30 times as potent in lowering plasma triglyceride concentration.

Approval Year

PubMed

Title	Date	PubMed
Treloxinate and related hypolipidemic 12H-dibenzo(d,g)(1,3)dioxocin-6-carboxylate derivatives.	1972-12	4635973

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:01:01 GMT 2025` Edited by `admin` on `Mon Mar 31 18:01:01 GMT 2025`
Record UNII	7YA71JCD50
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRELOXINATE

Official Name

English

NSC-162487

Preferred Name

English

treloxinate [INN]

Common Name

English

Methyl 2,10-dichloro-12H-dibenzo[d,g][1,3]dioxocin-6-carboxylate

Systematic Name

English

TRELOXINATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29703