BRENTUXIMAB VEDOTIN

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|TOXIN CONJUGATE
Sequence Origin	MOUSE CHIMERIC
Sequence Type	COMPLETE
Record UNII	7XL5ISS668
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BRENTUXIMAB VEDOTIN

Official Name

English

BRENTUXIMAB VEDOTIN [VANDF]

Common Name

English

SGN-35

Code

English

BRENTUXIMAB VEDOTIN (GENETICAL RECOMBINATION)

Official Name

English

Brentuximab vedotin [WHO-DD]

Common Name

English

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Classification Tree

Code System

Code

Biological Agent

NCI_THESAURUS

C1512

Positive

EU-Orphan Drug

EU/3/11/939

Designated/Approved

FDA ORPHAN DRUG

362611

Monoclonal antibodies

WHO-VATC

QL01XC12

Monoclonal Antibodies

LIVERTOX

NBK548844

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Code System

Code

Type

Description

LACTMED

Brentuximab Vedotin

PRIMARY

EVMPD

SUB32397

PRIMARY

SMS_ID

100000124524

PRIMARY

DRUG BANK

DB08870

PRIMARY

NCI_THESAURUS

C66944

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_96
1_144	1_200
1_220	3_218
1_226	2_226
1_229	2_229

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_297
N	2_297

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Related Record

Type

Details


					Q3606FDE0B

VEDOTIN FRAGMENT

CONJUGATE COMPONENT->CONJUGATE

Amount:


					4K108E14CS

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8

TARGET->CONJUGATED TOXIN

Comments:

The Kd for the 3 lots ranged from 1.92 +/- 0.77 to 2.64 +/- 0.94 nM. The Kd for the cAC10, the unconjugated antibody, was 1.38.

Interaction Type:

BINDING

Qualification:

Kd

Amount:

2.28 NANOMOLAR [1.92 to 2.64] (average)


					4K108E14CS

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8

TARGET -> INHIBITOR

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Related Record

Type

Details


					V7I58RC5EJ

MONOMETHYL AURISTATIN E

METABOLITE ACTIVE -> PARENT

Comments:

Addition of E64d, a cysteine protease inhibitor, blocked the release of MMAE

Qualification:

FECAL; URINE

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Related Record

Type

Details


					7XL5ISS668

BRENTUXIMAB VEDOTIN

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	NUMBER 150500 Da (average)
Molecular Formula	CHEMICAL	ESTIMATED C6476H9906N1690O2030S40

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