LY-487379

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H19F3N2O4S
Molecular Weight	452.447
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC=CC=C1OC2=CC=C(C=C2)N(CC3=CC=CN=C3)S(=O)(=O)CC(F)(F)F

InChI

InChIKey=ALMACYDZFBMGOR-UHFFFAOYSA-N

InChI=1S/C21H19F3N2O4S/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24/h2-13H,14-15H2,1H3

HIDE SMILES / InChI

Molecular Formula	C21H19F3N2O4S
Molecular Weight	452.447
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

N-(4-(2-Methoxyphenoxy)-phenyl-N-(2,2,2-trifluoroethylsulfonyl)-pyrid-3-ylmethylamine (LY487379) is a selective positive allosteric modulator at metabotropic glutamate subtype 2 receptors (mGluR2). The compound exerts antipsychotic and anxiolytic actions.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Metabotropic glutamate receptor 2 24	Positive Allosteric Modulator 179		1.7 µM [EC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schizophrenia 298	Primary		Preclinical	Unknown
Anxiety 267	Primary		Preclinical	Unknown

PubMed

Show entries

Title	Date	PubMed
Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.	2003 Jul 17	12852748
Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.	2003 Oct	14500736
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.	2005	15993439
A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.	2007 Jul	17416742
The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801.	2010 Aug 10	20371226