Ismidenon

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H12N2O
Molecular Weight	236.2686
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1N=C2C=CC=CN2C13CC4=CC=CC=C4C3

InChI

InChIKey=QZWYXEBIQWJXAR-UHFFFAOYSA-N

InChI=1S/C15H12N2O/c18-14-15(17-8-4-3-7-13(17)16-14)9-11-5-1-2-6-12(11)10-15/h1-8H,9-10H2

HIDE SMILES / InChI

Molecular Formula	C15H12N2O
Molecular Weight	236.2686
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17090702 | https://www.ncbi.nlm.nih.gov/pubmed/18388258 | https://www.ncbi.nlm.nih.gov/pubmed/20068029

ST-101 (also known as ZSET1446) is an azaindolizinone derivative patented by Zenyaku Kogyo Kabushiki Kaisha for the treatment of Alzheimer's disease and improvement of cerebral function. In preclinical models, ST-101 stimulates acetylcholine release and improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. Impaired neurogenesis observed in olfactory bulbectomized mice was significantly improved by chronic administration with ST-101. We confirmed that administration with mecamylamine, a nicotinic acetylcholine receptor antagonist, inhibits ST-101-enhanced neurogenesis in the dentate gyrus. ST-101 administration also restored decreased phosphorylation of Akt and extracellular signal-regulated kinase in the dentate gyrus of olfactory bulbectomized mice.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Voltage-gated T-type calcium channel alpha-1G subunit 8 Target ID: CHEMBL4641 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22251222 \| https://www.pharmacodia.com/yaodu/html/v1/chemicals/ee85e073c07e87d0df12a23e4ce7bb4e.html	Activator 1447

PubMed

Title	Date	PubMed
A novel cognitive enhancer, ZSET1446/ST101, promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice.	2010-04	20068029
Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus.	2008-07	18388258
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.	2007-06-09	17559680
A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.	2007-02	17090702
Effects of a novel cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat.	2006-06	16474004

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:28:08 GMT 2025` Edited by `admin` on `Mon Mar 31 22:28:08 GMT 2025`
Record UNII	7TTT61784C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ST-101

Preferred Name

English

Ismidenon

Official Name

English

ismidenon [INN]

Common Name

English

ISMIDENON [USAN]

Common Name

English

Spiro[imidazo[1,2-a]pyridine-3(2H),2?-[2H]inden]-2-one, 1?,3?-dihydro-

Systematic Name

English

AD101

Code

English

1?,3?-Dihydrospiro[imidazo[1,2-a]pyridine-3(2H),2?-[2H]inden]-2-one

Systematic Name

English

ST101

Code

English

1?,3?-Dihydro-2H-spiro[imidazo[1,2-a]pyridine-3,2?-inden]-2-one

Systematic Name

English

AD-101

Code

English

ZSET-1446

Code

English

Code System Code Type Description

DRUG BANK

DB12621