Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H12N2O |
Molecular Weight | 236.2686 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1N=C2C=CC=CN2C13CC4=C(C3)C=CC=C4
InChI
InChIKey=QZWYXEBIQWJXAR-UHFFFAOYSA-N
InChI=1S/C15H12N2O/c18-14-15(17-8-4-3-7-13(17)16-14)9-11-5-1-2-6-12(11)10-15/h1-8H,9-10H2
Molecular Formula | C15H12N2O |
Molecular Weight | 236.2686 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
ST-101 (also known as ZSET1446) is an azaindolizinone derivative patented by Zenyaku Kogyo Kabushiki Kaisha for the treatment of Alzheimer's disease and improvement of cerebral function. In preclinical models, ST-101 stimulates acetylcholine release and improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. Impaired neurogenesis observed in olfactory bulbectomized mice was significantly improved by chronic administration with ST-101. We confirmed that administration with mecamylamine, a nicotinic acetylcholine receptor antagonist, inhibits ST-101-enhanced neurogenesis in the dentate gyrus. ST-101 administration also restored decreased phosphorylation of Akt and extracellular signal-regulated kinase in the dentate gyrus of olfactory bulbectomized mice.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:04:17 UTC 2023
by
admin
on
Sat Dec 16 09:04:17 UTC 2023
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Record UNII |
7TTT61784C
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Record Status |
Validated (UNII)
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Record Version |
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DB12621
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300000021771
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10220323
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C202605
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7TTT61784C
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887603-94-3
Created by
admin on Sat Dec 16 09:04:17 UTC 2023 , Edited by admin on Sat Dec 16 09:04:17 UTC 2023
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