Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C38H70N2O13 |
| Molecular Weight | 762.968 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 18 / 18 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]2(O[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)\C(=N\OC)[C@H](C)C[C@@](C)(O)[C@]([H])(O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@H]2C
InChI
InChIKey=HPZGUSZNXKOMCQ-SQYJNGITSA-N
InChI=1S/C38H70N2O13/c1-15-26-38(10,46)31(42)21(4)28(39-48-14)19(2)17-36(8,45)33(53-35-29(41)25(40(11)12)16-20(3)49-35)22(5)30(23(6)34(44)51-26)52-27-18-37(9,47-13)32(43)24(7)50-27/h19-27,29-33,35,41-43,45-46H,15-18H2,1-14H3/b39-28+/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
| Molecular Formula | C38H70N2O13 |
| Molecular Weight | 762.968 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 18 / 18 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Lexithromycin is an early semi-synthetic erythromycin, prepared by reaction of the 9-keto moiety to methyl oxime. Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability. Like all erythromycins, lexithromycin shows broad spectrum antibacterial activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:09:07 GMT 2023
by
admin
on
Sat Dec 16 05:09:07 GMT 2023
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| Record UNII |
7QKO29734U
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C261
Created by
admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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| Code System | Code | Type | Description | ||
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6532846
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118244-59-0
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53066-26-5
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7QKO29734U
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admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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6785
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admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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C87760
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CHEMBL2106397
Created by
admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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100000082287
Created by
admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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SUB08499MIG
Created by
admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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CC-11
Created by
admin on Sat Dec 16 05:09:07 GMT 2023 , Edited by admin on Sat Dec 16 05:09:07 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
