Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H15N4 |
| Molecular Weight | 299.3492 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
C1=CC=C(C=C1)N2N=C(N=[N+]2C3=CC=CC=C3)C4=CC=CC=C4
InChI
InChIKey=LNOBZXNCABUBKK-UHFFFAOYSA-N
InChI=1S/C19H15N4/c1-4-10-16(11-5-1)19-20-22(17-12-6-2-7-13-17)23(21-19)18-14-8-3-9-15-18/h1-15H/q+1
| Molecular Formula | C19H15N4 |
| Molecular Weight | 299.3492 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
2,3,5-Triphenyltetrazolium Chloride (TTC) is a redox indicator. In the TTC assay (also known as TTC test or tetrazolium test), TTC is used to differentiate between metabolically active and inactive tissues or cells. The white compound is enzymatically reduced to red TPF (1,3,5-triphenylformazan) in living tissues or cells due to the activity of various dehydrogenases (enzymes important in oxidation of organic compounds and thus cellular metabolism), while it remains as white TTC in areas of necrosis since these enzymes have been either denatured or degraded. TTC test is a reliable, sensitive, and specific adjunct in the examination of the human heart at necropsy to diagnose acute myocardial infarction in the human population. In addition TTC test may be used for diagnostics of bacteriuria.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The triphenyl tetrazolium chloride (uroscreen) test alone and in combination with the gram smear as a screening procedure for significant bacteriuria in hospital patients. | 1966 Jul 2 |
|
| Use of a solid reagent in the triphenyl tetrazolium chloride test for bacteriuria. | 1967 Sep |
|
| Sensitivity and specificity of triphenyl tetrazolium chloride in the gross diagnosis of acute myocardial infarcts. | 1997 Oct |
|
| An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. | 2004 Apr |
|
| Rapid and low-cost colorimetric method using 2,3,5-triphenyltetrazolium chloride for detection of multidrug-resistant Mycobacterium tuberculosis. | 2006 Dec |
|
| Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis. | 2012 Jan 15 |
|
| The effectiveness and limitations of triphenyltetrazolium chloride to detect acute myocardial infarction at forensic autopsy. | 2013 Sep |
Sample Use Guides
Eleven multidrug-resistant (MDR) isolates of M. tuberculosis and 12 isolates which were susceptible to rifampicin (RIF) and isoniazid (INH) were used. The test was performed with a critical concentration of 0.2 ug/ml for INH and 2.0 ug/ml for RIF in 7H9GC broth with 0.625 ug/ml 2,3,5-triphenyltetrazolium chloride (TTC). Each isolate was inoculated under these conditions and inspected daily for colour changes; the results were obtained after a mean of 4.9 days.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:37:47 GMT 2023
by
admin
on
Fri Dec 15 19:37:47 GMT 2023
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| Record UNII |
7OL20RET2I
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| Record Status |
Validated (UNII)
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| Record Version |
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7OL20RET2I
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C009591
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9284
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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IONIC MOIETY |
