Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C24H30O5 |
Molecular Weight | 398.492 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C3CCCCC3)[C@@]1([H])C\C(O2)=C\C4=CC=CC(=C4)C(O)=O
InChI
InChIKey=ZLJOKYGJNOQXDP-OZUBPDBUSA-N
InChI=1S/C24H30O5/c25-21(16-6-2-1-3-7-16)10-9-19-20-13-18(29-23(20)14-22(19)26)12-15-5-4-8-17(11-15)24(27)28/h4-5,8-12,16,19-23,25-26H,1-3,6-7,13-14H2,(H,27,28)/b10-9+,18-12-/t19-,20-,21-,22-,23+/m1/s1
Molecular Formula | C24H30O5 |
Molecular Weight | 398.492 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 2 |
Optical Activity | UNSPECIFIED |
Taprostene (also known as CG 4203), a stable prostacyclin (PGI2) analog was developed by Gruenenthal as a selective agonist of the prostanoid receptor IP1. Taprostene was studied in a clinical trial in patients with acute myocardial infarction, where it was shown that the drug could be a useful adjuvant to thrombolytic agents in acute myocardial infarction. In addition, taprostene participated in a clinical trial for the treatment of critical limb ischemia, where the drug was safe and effective. Besides taprostene was studied in patients with advanced peripheral arterial disease. However, further development of the drug was discontinued.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Role of renin release in the hemodynamic, renal and dipsogenic actions of the prostacyclin analogue CG 4203 in conscious rats. | 1983 Aug |
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Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. | 1997 Apr |
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Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. | 2012 Jul 1 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8404943
Three doses of taprostene were used: 6.25; 12.5; or 25.0 ng.kg-1 x min-1.
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:35:16 GMT 2023
by
admin
on
Fri Dec 15 16:35:16 GMT 2023
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Record UNII |
7MS1HEY2IZ
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C1327
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DTXSID50872496
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7MS1HEY2IZ
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108945-35-3
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100000082424
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6188
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CHEMBL2104890
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5311243
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C76403
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m10460
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C039188
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SUB10831MIG
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Related Record | Type | Details | ||
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