LISOCABTAGENE MARALEUCEL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Tue Apr 01 22:12:14 GMT 2025` Edited by `admin` on `Tue Apr 01 22:12:14 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	cd4+ and cd8+ cd3+ t-cells
Record UNII	7K2YOJ14X0
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BREYANZI

Preferred Name

English

LISOCABTAGENE MARALEUCEL

Official Name

English

JCAR-017

Code

English

JCAR017

Code

English

LISOCABTAGENE MARALEUCEL [USAN]

Common Name

English

Lisocabtagene maraleucel [WHO-DD]

Common Name

English

lisocabtagene maraleucel [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

516115

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

FDA ORPHAN DRUG

933623

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

FDA ORPHAN DRUG

644018

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

NCI_THESAURUS

C129826

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

FDA ORPHAN DRUG

600517

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

FDA ORPHAN DRUG

730920

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

FDA ORPHAN DRUG

933723

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

NCI_THESAURUS

C28681

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

EU-Orphan Drug

EU/3/18/2099

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

NCI_THESAURUS

C137999

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

FDA ORPHAN DRUG

933823

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

Code System Code Type Description

SMS_ID

100000176403

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

RXCUI

2479136

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

INN

10805

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

FDA UNII

7K2YOJ14X0

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

DAILYMED

7K2YOJ14X0

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

USAN

EF-26

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

NCI_THESAURUS

C125192

Created by admin on Tue Apr 01 22:12:14 GMT 2025 , Edited by admin on Tue Apr 01 22:12:14 GMT 2025

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					7K2YOJ14X0

LISOCABTAGENE MARALEUCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
TRANSDUCTION OF EXPRESSION VECTOR	RECEPTOR EXPRESSION	RETROVIRAL TRANSFECTION		LISOCABTAGENE MARALEUCEL LENTIVIRUS VECTOR	TO1TNB1HUL

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					LISOCABTAGENE MARALEUCEL TRANSGENE INSERT	939TQL8M8R
VECTOR EXPRESSED PROTEIN					UNSPECIFIED SUBSTANCE	1cd64bba (not in database)
CAR-T RECEPTOR					LISOCABTAGENE MARALEUCEL CAR-T RECEPTOR	E18VZQ3GB1

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
CD4/CD8 RATIO	IMMUNOLOGICAL