JNJ-10191584

CN1CCN(CC1)C(=O)C2=NC3=CC=C(Cl)C=C3N2

InChIKey=MOIWSUQWIOVGRH-UHFFFAOYSA-N

InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H4 receptor 20 Target ID: CHEMBL3759 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16366610	Antagonist 2778		26.0 nM [Ki]
Histamine H3 receptor 44 Target ID: CHEMBL264 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16366610	Binding Agent 1064		14.0 µM [Ki]

PubMed

Title	Date	PubMed
		252160039
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.	2005 Dec 29	16366610
Molecular determinants of ligand binding to H4R species variants.	2010 May	20103609

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:02:21 UTC 2023` Edited by `admin` on `Sat Dec 16 08:02:21 UTC 2023`
Record UNII	7EE5T3WL8P
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

JNJ-10191584

Common Name

English

PIPERAZINE, 1-((5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL)-4-METHYL-

Systematic Name

English

VUF-6002

Code

English

METHANONE, (6-CHLORO-1H-BENZIMIDAZOL-2-YL)(4-METHYL-1-PIPERAZINYL)-

Systematic Name

English

(5-CHLORO-1H-BENZIMIDAZOL-2-YL)(4-METHYLPIPERAZIN-1-YL)METHANONE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

JNJ-10191584