ARFALASIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C48H67N13O11
Molecular Weight	1002.1261
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N3CCC[C@H]3C(=O)N[C@H](C(O)=O)C4=CC=CC=C4

InChI

InChIKey=IBGNPQRJAXAGJH-MBNHCIONSA-N

InChI=1S/C48H67N13O11/c1-26(2)38(58-41(65)32(12-8-20-53-48(50)51)55-37(64)19-18-36(49)63)44(68)56-33(22-28-14-16-31(62)17-15-28)42(66)59-39(27(3)4)45(69)57-34(23-30-24-52-25-54-30)46(70)61-21-9-13-35(61)43(67)60-40(47(71)72)29-10-6-5-7-11-29/h5-7,10-11,14-17,24-27,32-35,38-40,62H,8-9,12-13,18-23H2,1-4H3,(H2,49,63)(H,52,54)(H,55,64)(H,56,68)(H,57,69)(H,58,65)(H,59,66)(H,60,67)(H,71,72)(H4,50,51,53)/t32-,33-,34-,35-,38-,39-,40-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C48H67N13O11
Molecular Weight	1002.1261
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6399315

Arfalasin or Hoe 409, an angiotensin II (AII) blocker, inhibits the renin release thus delay recovery of urinary osmolality.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:07:27 GMT 2023` Edited by `admin` on `Fri Dec 15 16:07:27 GMT 2023`
Record UNII	7E6SP93I57
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARFALASIN

Official Name

English

arfalasin [INN]

Common Name

English

1-SUCCINAMIC ACID-5-L-VALINE-8-(L-2-PHENYLGLYCINE)ANGIOTENSIN II

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66930