ARFALASIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C48H67N13O11
Molecular Weight	1002.1261
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N3CCC[C@H]3C(=O)N[C@H](C(O)=O)C4=CC=CC=C4

InChI

InChIKey=IBGNPQRJAXAGJH-MBNHCIONSA-N

InChI=1S/C48H67N13O11/c1-26(2)38(58-41(65)32(12-8-20-53-48(50)51)55-37(64)19-18-36(49)63)44(68)56-33(22-28-14-16-31(62)17-15-28)42(66)59-39(27(3)4)45(69)57-34(23-30-24-52-25-54-30)46(70)61-21-9-13-35(61)43(67)60-40(47(71)72)29-10-6-5-7-11-29/h5-7,10-11,14-17,24-27,32-35,38-40,62H,8-9,12-13,18-23H2,1-4H3,(H2,49,63)(H,52,54)(H,55,64)(H,56,68)(H,57,69)(H,58,65)(H,59,66)(H,60,67)(H,71,72)(H4,50,51,53)/t32-,33-,34-,35-,38-,39-,40-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C48H67N13O11
Molecular Weight	1002.1261
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6399315

Arfalasin or Hoe 409, an angiotensin II (AII) blocker, inhibits the renin release thus delay recovery of urinary osmolality.

Approval Year

PubMed

Title	Date	PubMed
Is the renin-angiotensin system involved in urinary concentration mechanisms?	1984	6399315

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:07:27 GMT 2023` Edited by `admin` on `Fri Dec 15 16:07:27 GMT 2023`
Record UNII	7E6SP93I57
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARFALASIN

Official Name

English

arfalasin [INN]

Common Name

English

1-SUCCINAMIC ACID-5-L-VALINE-8-(L-2-PHENYLGLYCINE)ANGIOTENSIN II

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66930