LYPRESSIN

Description
Sources: https://www.drugs.com/mmx/diapid.html
Curator's Comment: description was created based on several sources, including http://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=016755

Lypressin is synthetic analog of porcine antidiuretic hormone vasopressin. Itis a cyclic nonapeptide that differs from Arg-vasopressin by one amino acid, containing Lys at residue 8 instead of Arg. Lypressin-containing nasal spray was used to treat diabetes insipidus, but its marketing by Sandoz (Novartis) was discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Vasopressin receptor 5 Target ID: CHEMBL2363078 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8393786	Agonist 2752		7.3 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes insipidus 4 Sources: https://www.drugs.com/mmx/diapid.html	Palliative		Approved 8583	DIAPID Approved Use Increases water reabsorption in the kidney by increasing the cellular permeability of the collecting ducts, resulting in an increase in urine osmolality with a concurrent decrease in urine output. Lypressin is indicated for the prevention or control of polydipsia, polyuria, and dehydration associated with central diabetes insipidus caused by insufficient antidiuretic hormone.

PubMed

Title	Date	PubMed
1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives.	1993-06	8370109
[Effect of lysyl vasopressin and vasotocin on a disorder of the conditioned avoidance reaction by a serotonin receptor blockader].	1983-02	6824771

Patents

Sample Use Guides

In Vivo Use Guide

Adults: lypressin spray (diapid) contains contains approximately 0.007 mg lypression per spray. (equivalent to 2 Posterior Pituitary Units). For treatment of diabetes insipidus, 1-2 sprays should be administered in each nostril 4 times daily.

Route of Administration: Nasal

In Vitro Use Guide

V2[Lys8]VP-receptor was transfected into COS7 cells. The displacement experiments were performed with 10 nM [3H] [Arg8]VP in the presence of 0.1 - 10000 nM lypressin. Incubation was performed for 30 min at 30°C in duplicate. Bound ligand was separated from free ligand by filtering the incubation mixture through Whatman GF/B filters soaked in 0.05% bovine serum albumin. Lypressin binds to vasopressin receptor with Ki of 7.3 nM.

Substance Class	Protein Created by `admin` on `Mon Mar 31 18:19:51 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:51 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	7CZF3L922Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIAPID

Preferred Name

English

LYPRESSIN

Official Name

English

LYPRESSIN [USAN]

Common Name

English

L-CYSTEINYL-L-TYROSYL-L-PHENYLALANYL-L-GLUTAMINYL-L-ASPARAGINYL-L-CYSTEINYL-L-PROLYL-L-LYSYLGLYCINAMIDE CYCLIC (1->6)-DISULFIDE

Common Name

English

L-CYSTEINYL-L-TYROSYL-L-PHENYLALANYL-L-GLUTAMINYL-L-ASPARAGINYL-L-CYSTEINYL-L-PROLYL-L-LYSYLGLYCINAMIDE CYCLIC (1->6)-DISULPHIDE

Common Name

English

LYPRESSIN [ORANGE BOOK]

Common Name

English

LYPRESSIN [MI]

Common Name

English

LYPRESSIN [USP IMPURITY]

Common Name

English

8-L-LYSINEVASOPRESSIN

Common Name

English

Lypressin [WHO-DD]

Common Name

English

LYPRESSIN [USP-RS]

Common Name

English

LYSINE VASOPRESSIN

Common Name

English

L-8

Code

English

LYPRESSIN [VANDF]

Common Name

English

VASOPRESSIN, 8-L-LYSINE

Common Name

English

LYPRESSIN [MART.]

Common Name

English

lypressin [INN]

Common Name

English

VASOPRESSIN PIG

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C80212