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Description

Lypressin is synthetic analog of porcine antidiuretic hormone vasopressin. Itis a cyclic nonapeptide that differs from Arg-vasopressin by one amino acid, containing Lys at residue 8 instead of Arg. Lypressin-containing nasal spray was used to treat diabetes insipidus, but its marketing by Sandoz (Novartis) was discontinued.

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
7.3 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DIAPID
PubMed

PubMed

TitleDatePubMed
[Effect of lysyl vasopressin and vasotocin on a disorder of the conditioned avoidance reaction by a serotonin receptor blockader].
1983 Feb
1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives.
1993 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Adults: lypressin spray (diapid) contains contains approximately 0.007 mg lypression per spray. (equivalent to 2 Posterior Pituitary Units). For treatment of diabetes insipidus, 1-2 sprays should be administered in each nostril 4 times daily.
Route of Administration: Nasal
In Vitro Use Guide
V2[Lys8]VP-receptor was transfected into COS7 cells. The displacement experiments were performed with 10 nM [3H] [Arg8]VP in the presence of 0.1 - 10000 nM lypressin. Incubation was performed for 30 min at 30°C in duplicate. Bound ligand was separated from free ligand by filtering the incubation mixture through Whatman GF/B filters soaked in 0.05% bovine serum albumin. Lypressin binds to vasopressin receptor with Ki of 7.3 nM.
Substance Class Protein
Created
by admin
on Tue Oct 22 00:36:18 UTC 2019
Edited
by admin
on Tue Oct 22 00:36:18 UTC 2019
Protein Sub Type
Sequence Type COMPLETE
Record UNII
7CZF3L922Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LYPRESSIN
INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
LYPRESSIN [USAN]
Common Name English
L-CYSTEINYL-L-TYROSYL-L-PHENYLALANYL-L-GLUTAMINYL-L-ASPARAGINYL-L-CYSTEINYL-L-PROLYL-L-LYSYLGLYCINAMIDE CYCLIC (1->6)-DISULFIDE
Common Name English
L-CYSTEINYL-L-TYROSYL-L-PHENYLALANYL-L-GLUTAMINYL-L-ASPARAGINYL-L-CYSTEINYL-L-PROLYL-L-LYSYLGLYCINAMIDE CYCLIC (1->6)-DISULPHIDE
Common Name English
LYPRESSIN [USP]
Common Name English
LYPRESSIN [ORANGE BOOK]
Common Name English
LYPRESSIN [MI]
Common Name English
DIAPID
Brand Name English
8-L-LYSINEVASOPRESSIN
Common Name English
LYPRESSIN [WHO-DD]
Common Name English
LYPRESSIN [USP-RS]
Common Name English
LYSINE VASOPRESSIN
Common Name English
L-8
Code English
LYPRESSIN [VANDF]
Common Name English
VASOPRESSIN, 8-L-LYSINE
Common Name English
LYPRESSIN [MART.]
Common Name English
LYPRESSIN [INN]
Common Name English
VASOPRESSIN PIG
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C80212
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
WHO-VATC QH01BA03
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
WHO-ATC H01BA03
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
Code System Code Type Description
INN
1481
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
CAS
50-57-7
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
NCI_THESAURUS
C66044
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
ECHA (EC/EINECS)
200-050-5
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
MESH
D008236
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
EVMPD
SUB08627MIG
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
EPA CompTox
50-57-7
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
MERCK INDEX
M6961
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY Merck Index
PUBCHEM
644076
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
ChEMBL
CHEMBL1200690
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY
RXCUI
6531
Created by admin on Tue Oct 22 00:36:18 UTC 2019 , Edited by admin on Tue Oct 22 00:36:18 UTC 2019
PRIMARY RxNorm
From To
1_1 1_6
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Believed to behave as a prodrug
IN-VIVO
PLASMA
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL