U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:21:37 GMT 2023
Edited
by admin
on Sat Dec 16 18:21:37 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name T CELLS
Record UNII
7CH7MR6SN5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MOTACABTAGENE LUREVGEDLEUCEL
INN  
Official Name English
ALLOGENEIC T CELLS OBTAINED FROM PERIPHERAL BLOOD BY LEUKAPHERESIS, GENETICALLY MODIFIED BY CRISPR/CAS9 (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 9) MEDIATED GENE EDITING CONSISTING OF TWO GUIDE RNAS (GRNAS) INT
Common Name English
motacabtagene lurevgedleucel [INN]
Common Name English
Code System Code Type Description
INN
11721
Created by admin on Sat Dec 16 18:21:37 GMT 2023 , Edited by admin on Sat Dec 16 18:21:37 GMT 2023
PRIMARY
FDA UNII
7CH7MR6SN5
Created by admin on Sat Dec 16 18:21:37 GMT 2023 , Edited by admin on Sat Dec 16 18:21:37 GMT 2023
PRIMARY
NCI_THESAURUS
C172741
Created by admin on Sat Dec 16 18:21:37 GMT 2023 , Edited by admin on Sat Dec 16 18:21:37 GMT 2023
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CRISPR GENE TRUNCATION EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE TRAC LOCUS FKP72X9XKK
TRANSFECTION MOTACABTAGENE LUREVGEDLEUCEL VECTOR B2W33RXV75
CULTURE EXPANSION HUMAN INTERLEUKIN-2 FNO32LO217
CULTURE EXPANSION INTERLEUKIN-7 HUMAN RECOMBINANT 418XB47Y71
CRISPR GENE TRUNCATION EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE .BETA.2M LOCUS EQW8RVL4CV

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN MOTACABTAGENE LUREVGEDLEUCEL EXPRESSED CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING B-CELL MATURATION ANTIGEN (BCMA) A9SFR34QU8
INSERTED GENE EXPRESSION VECTOR MOTACABTAGENE LUREVGEDLEUCEL TRANSGENE INSERT 5AX55JEG65