MECINARONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H27NO6
Molecular Weight	425.4743
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(\C=C\C(=O)C2=C(OCCN(C)C)C(OC)=C3OC=CC3=C2OC)C=C1

InChI

InChIKey=WKEFCGWXBSXUOD-DHZHZOJOSA-N

InChI=1S/C24H27NO6/c1-25(2)13-15-31-23-20(19(26)11-8-16-6-9-17(27-3)10-7-16)21(28-4)18-12-14-30-22(18)24(23)29-5/h6-12,14H,13,15H2,1-5H3/b11-8+

HIDE SMILES / InChI

Molecular Formula	C24H27NO6
Molecular Weight	425.4743
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1242324 | https://www.ncbi.nlm.nih.gov/pubmed/658138 | https://www.ncbi.nlm.nih.gov/pubmed/288357

Mecinarone is a benzofuranic chalcone. It exerts vasodilating activity. Mecinarone has also antibradykinin, antiserotonin and antiaggregation properties. Mecinarone induces an increase of melanin content of pigmented skin and mucosae.

Approval Year

PubMed

Title	Date	PubMed
Apparent tropism of a vasodilator, mecinarone, for melanin-containing tissues and activation of melanogenesis in the beagle [proceedings].	1979	288357
Vascular and myocardial effects of mecinarone.	1978-06-01	658138
Pharmacological study of a new substance, mecinarone.	1975-05	1242324

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:09 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:09 GMT 2025`
Record UNII	7B1550J80K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(6-(2-(DIMETHYLAMINO)ETHOXY)-4,7-DIMETHOXY-5-BENZOFURANYL)-3-(P-METHOXYPHENYL)-2-PROPEN-1-ONE

Preferred Name

English

MECINARONE

Official Name

English

mecinarone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29707