DISUFENTON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H15NO7S2
Molecular Weight	337.369
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0
Stereo Comments	MM2 minimum energy of Z and E are 288.5886 and 451.3651 kcal/mol respectively

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)[N+](\[O-])=C\C1=C(C=C(C=C1)S(O)(=O)=O)S(O)(=O)=O

InChI

InChIKey=OVTCHWSLKGENKP-GHXNOFRVSA-N

InChI=1S/C11H15NO7S2/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19)/b12-7-

HIDE SMILES / InChI

Molecular Formula	C11H15NO7S2
Molecular Weight	337.369
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16467546 | https://www.ncbi.nlm.nih.gov/pubmed/28832600 | https://www.ncbi.nlm.nih.gov/pubmed/29673616

AstraZeneca developed disufenton (NXY-059), a free radical trapping agent, for the treatment of ischaemic stroke and other brain injuries. Nevertheless, large clinical trial (3306 versus 1722 patients) was neutral, providing no evidence for the efficacy of disufenton sodium in patients with stroke. One study using rat cortical brain slices concluded that NXY-059 improved neuronal survival. However, another study in mouse neuroblastoma cells reported no effect. Another study reported that NXY-059 restored endothelial blood-brain. Histological analyses revealed several therapeutic advantages associated with disufenton sodium treatment following acute acoustic trauma, including reductions in inner and outer hair cell loss; reductions in acute acoustic trauma-induced loss of calretinin-positive afferent nerve fibers in the spiral lamina; and reductions in fibrocyte loss within the spiral ligament. However, AstraZeneca terminated the development program.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Free radical 2 Target ID: Free radical Sources: https://www.ncbi.nlm.nih.gov/pubmed/29673616	Chelating Agent 142

PubMed

Title	Date	PubMed
		252160420
NXY-059 does not significantly interact with furosemide in healthy volunteers.	2006 Dec	17101741
Neuroprotection for stroke: current status and future perspectives.	2012	23109881
Neuroprotection for ischaemic stroke: translation from the bench to the bedside.	2012 Jul	22394615
Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics.	2012 Jun	22709256
Commentary : Hypothesis Focused Ultrasound and NXY-059 in Experimental Cerebral Ischemia: A New Therapeutic Opportunity?	2016	27680203
HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma.	2017	28832600
NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons.	2018 Aug	29673616

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:42:03 GMT 2023` Edited by `admin` on `Fri Dec 15 15:42:03 GMT 2023`
Record UNII	797K01YF1M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DISUFENTON

Common Name

English

4-TERT-BUTYLIMINOMETHYL)BENZENE-,3-DISULPHONATE N-OXIDE

Common Name

English

2,4-DISULFONYL-.ALPHA.-PHENYL-TERT-BUTYLNITRONE

Common Name

English

Disufenton [WHO-DD]

Common Name

English

1,3-BENZENEDISULFONIC ACID, 4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)-

Common Name

English

4-TERT-BUTYLIMINOMETHYL)BENZENE-,3-DISULFONATE N-OXIDE

Common Name

English

4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)-1,3-BENZENEDISULFONIC ACID

Common Name

English

2,4-disulfonyl PBN

Common Name

English

DISUFENTON [MI]

Common Name

English

4-(((1,1-DIMETHYLETHYL)IMINO)METHYL)BENZENE-1,3-DISULFONATE N-OXIDE

Common Name

English

4-(((1,1-DIMETHYLETHYL)IMINO)METHYL)BENZENE-1,3-DISULPHONATE N-OXIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509