CHLORINDANOL

US Previously Marketed

First approved in 1959

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H9ClO
Molecular Weight	168.62
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C2CCCC2=C(Cl)C=C1

InChI

InChIKey=ATAJVFBUUIBIEO-UHFFFAOYSA-N

InChI=1S/C9H9ClO/c10-8-4-5-9(11)7-3-1-2-6(7)8/h4-5,11H,1-3H2

HIDE SMILES / InChI

Molecular Formula	C9H9ClO
Molecular Weight	168.62
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14298013 | https://www.ncbi.nlm.nih.gov/pubmed/13641056 | https://www.ncbi.nlm.nih.gov/pubmed/5467821

Chlorindanol is an antiseptic agent which is rapidly leathal to vegetative bacteria (Trichophyton sp., C. albicans, E. histolytica cysts and trophozoites, T. vaginalis) and seprmatozoa in vitro. It is one of two active ingredients in a spermicidal contraceptive aerosol cream (Lanettes); with the other being laureth-9.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Yeast fungal infection 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5467821	Primary		Basic research	Unknown Approved Use Unknown
Pregnancy 65 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14298013	Primary		Not Provided 511	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY459862	https://www.001chemical.com/chem/145-94-8
AA Blocks	AA001KCP	https://www.aablocks.com/goods/Goods/detail?id=AA001KCP
Aaron Chemicals	AR001L4H	http://www.aaronchem.com/145-94-8
abcr GmbH	AB436128	http://www.abcr.com/shop/en/AB436128
Acadechem	ACDS-034116	http://www.acadechemical.com/product/108815
Acorn PharmaTech	ACN-025162	http://www.acornpharmatech.com/
AHH Chemical co.,ltd	MR-1000898	http://www.ahhchemical.com/product/MR-1000898.html
AK Scientific, Inc. (AKSCI)	7221AA	http://www.aksci.com/item_detail.php?cat=7221AA
Anward	ANW-72332	http://www.anward.com/pro_result/58783
Ark Pharm	AK-42152	http://www.arkpharminc.com/products/145-94-8.html
BLD Pharm	BD110488	http://www.bldpharm.com/products/145-94-8.html
Chem Scene	CS-4493	http://www.chemscene.com/145-94-8.html
Chemenu	CM132182	http://www.chemenu.com/products/CM132182
ChemMol	49426772	http://www.chemmol.com/chemmol/49426772.html
Chemspace	CSSB00000073669	https://chem-space.com/CSSB00000073669
DC Chemicals	DC36838	http://www.dcchemicals.com//product_show-Chlorindanol.html
Debye Scientific	DB-049773	http://www.debyesci.com/cas_145-94-8.html
eNovation Chemicals	D145419	https://www.enovationchem.com/ProductDetails.asp?ProductID=D145419
eNovation Chemicals	D952126	https://www.enovationchem.com/ProductDetails.asp?ProductID=D952126
Finetech	FT-0660863	http://www.finetechnology-ind.com/prod/detail/pub/145-94-8.html
Hairui	HR104756	http://www.hairuichem.com/en/product/145-94-8.html
Hefei Hirisun Pharmatech Co., Ltd	HR010431	http://www.hirisunpharm.com/145-94-8.html
Huateng Pharma	F99572	https://en.huatengsci.com/products/intermediates/
iChemical	EBD13219	http://www.ichemical.com/chemicals/cas-145-94-8
Lab Network	LN00188822	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00188822
Matrix Scientific	149428	https://www.matrixscientific.com/149428.html
mcule	MCULE-8770381110	https://mcule.com/MCULE-8770381110/
MedChem Express	HY-B0999	https://www.medchemexpress.com/Chlorindanol.html
Molcore	MC459862	https://www.molcore.com/product/145-94-8
MuseChem	I001768	https://www.musechem.com/product/I001768.html
OChem	12133	http://www.ocheminc.com/index.php?act=psearch&pid=145C948
Sigma-Aldrich	S544752_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/s544752
Sinfoo Biotech	S018459	http://www.sinfoobiotech.com/product/1021857
Smolecule	S523497	http://www.smolecule.com/products/s523497
THE BioTek	bt-264155	https://www.thebiotek.com/product/inhibitors/bt-264155

PubMed

Title	Date	PubMed
[Effect of chlorindanol on fungi in vitro].	1970-04	5467821
TOXICOLOGY AND SPERMICIDAL ACTIVITY OF A NEW CONTRACEPTIVE CREAM CONTAINING CHLORINDANOL AND LAURETH 9.	1965-03	14298013
The biological properties of chlorindanol, a new antiseptic agent.	1959-04	13641056

Patents

Sample Use Guides

In Vivo Use Guide

A spermicidal aerosol cream marketed under the name Lanettes contains 0.1 % w/w Chlorindanol as one of two active ingredients. Instructions for use describe liberal application inside the vagina and to the penile surface.

Route of Administration: Topical

In Vitro Use Guide

The antifungal properties of chlorindanol were assesed against yeast fungal species including Candida albicans, C. tropicalis, C. parapsilosis, C. pseudotropicalis, C. stellatoidea, C. guilliermondii, C. krusei and Torulopsis glabrata. Chlorindanol was prepared in 5% propylene glycol. Chlorindanol was found to be fungicidal at a concentration of 60 - 80 microg/mL/24 hours and fungistatic at a concentration of 20 - 40 microg/mL/24 hours. Similar activities were obseved for cultures in human seerum.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:51 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:51 GMT 2025`
Record UNII	7902N03BH0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLORINDANOL

Preferred Name

English

CHLORINDANOL

Official Name

English

CLORINDANOL [MART.]

Common Name

English

7-Chloro-4-indanol

Systematic Name

English

clorindanol [INN]

Common Name

English

NSC-158565

Code

English

CHLORINDANOL [HSDB]

Common Name

English

CHLORINDANOL [USAN]

Common Name

English

CHLORINDANOL [MI]

Common Name

English

1H-INDEN-4-OL, 7-CHLORO-2,3-DIHYDRO-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394