Tiprelestat (Elafin) is a potent Human neutrophil elastase inhibitor. Elafin is identical to the human protein elafin with high specificity for tissue destroying and inflammation promoting proteases. The development program of Elafin is focused on the late stage development of Elafin in major surgery and early stage development in pulmonary arterial hypertension (PAH). Elafin has received orphan drug designations in the USA and the EU for esophageal cancer surgery (ECS) and PAH. Tiprelestat is in phase II clinical trials for the treatment of myocardial reperfusion injury, postoperative inflammation and in phase I clinical trial for the treatment of pulmonary arterial hypertension.
Originator
Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 05:45:45 UTC 2023
by
admin
on
Sat Dec 16 05:45:45 UTC 2023
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| Protein Type | ENZYME INHIBITOR |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
78I8295690
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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FDA ORPHAN DRUG |
241007
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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FDA ORPHAN DRUG |
364612
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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NCI_THESAURUS |
C783
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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EU-Orphan Drug |
EU/3/09/710
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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C152650
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY | |||
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9252
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY | |||
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820211-82-3
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY | |||
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78I8295690
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY | |||
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CHEMBL2108349
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY | |||
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DTXSID00231519
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY | |||
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44201346
Created by
admin on Sat Dec 16 05:45:45 UTC 2023 , Edited by admin on Sat Dec 16 05:45:45 UTC 2023
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PRIMARY |
| From | To |
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| 1_16 | 1_45 |
| 1_23 | 1_49 |
| 1_32 | 1_44 |
| 1_38 | 1_53 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
Ki
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
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