Insulin Argine is a human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. The primary activity of insulin, including Insulin Argine, is the regulation of glucose metabolism. Insulin and its analog lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin Argine differs from human insulin in that two arginines are added to the C-terminus of the B-chain. Unfortunately Insulin Argine failed to demonstrate superior efficacy to regular human insulin and clinical development was discontinued