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Details

Stereochemistry ABSOLUTE
Molecular Formula C9H12N2O4S
Molecular Weight 244.268
Optical Activity ( - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIDOTIMOD

SMILES

OC(=O)[C@@H]1CSCN1C(=O)[C@@H]2CCC(=O)N2

InChI

InChIKey=UUTKICFRNVKFRG-WDSKDSINSA-N
InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1

HIDE SMILES / InChI

Molecular Formula C9H12N2O4S
Molecular Weight 244.268
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Pidotimod is a synthetic dipeptide with immunomodulatory properties. An immunostimulant used in patients with cell-mediated immunodepression during resp and urinary tract infections. In vitro and in vivo laboratory studies show that treatment with pidotimod causes a significant induction of macrophage and neutrophil polymorphonuclear activity, which is characterized by an increase in spontaneous chemotaxis, superoxide anion production and phagocytosis. Several placebo-controlled trials of the drug have been carried out in various indications such as recurrent respiratory, pharyngotonsillar and urinary infections in children, and in adults with exacerbations of chronic bronchitis. For example, in 120 children with recurrent respiratory infections, pidotimod reduced relapse by 35%, hospitalization by 86% and antibiotic use by 47% compared to placebo.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Pidotimod
Primary
Pidotimod

Cmax

ValueDoseCo-administeredAnalytePopulation
5.57 μg/mL
800 mg single, oral
PIDOTIMOD plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
25.1 μg × h/mL
800 mg single, oral
PIDOTIMOD plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
1.82 h
800 mg single, oral
PIDOTIMOD plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
96%
PIDOTIMOD plasma
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
Take this medication by mouth, usually 2 to 3 times daily with a full glass of water (8 ounces or 240 milliliters) or as directed by your doctor. Do not lie down for at least 10 minutes after taking this drug.
Route of Administration: Oral
In Vitro Use Guide
Pidotimod 10 and 100 ug/ml increased TLR-2 expression in BEAS-2B cell line (human bronchial epithelial cells infected with a replication-defective Adenovirus 12-SV40 virus hybrid)
Substance Class Chemical
Record UNII
785363R681
Record Status Validated (UNII)
Record Version