CEFIVITRIL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H15N7O4S3
Molecular Weight	453.519
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@H]2NC(=O)CS\C=C/C#N)C(O)=O

InChI

InChIKey=JXHWKLWIYBATLL-GMIKGCRTSA-N

InChI=1S/C15H15N7O4S3/c1-21-15(18-19-20-21)29-6-8-5-28-13-10(12(24)22(13)11(8)14(25)26)17-9(23)7-27-4-2-3-16/h2,4,10,13H,5-7H2,1H3,(H,17,23)(H,25,26)/b4-2-/t10-,13-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C15H15N7O4S3
Molecular Weight	453.519
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7275820 | https://www.ncbi.nlm.nih.gov/pubmed/15032531

Cefivitril is a semi-synthetic cephalosporin with broad antibacterial activity against penicillin-resistant strains of S. aureus. Compared with the other cephalosporin, Cefivitril showed a better in vitro activity on gram pos. and gram neg. bacteria. Sensitivity tests were performed with 1007 bacterial strains to evaluate the in vitro activity of Cefivitril compared with that of cefuroxime and cephapirin. Compared with cefuroxiime and cephaprin, Cefivitril activity was significantly higher on Pasteurella and Salmonella, whereas no significant differences were detected for Streptococcus, Proteus, and Pseudomonas.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:56 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:56 GMT 2023`
Record UNII	776E09GMHQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CEFIVITRIL

Official Name

English

cefivitril [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C357