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Details

Stereochemistry ACHIRAL
Molecular Formula C28H40N4S.C4H4O4
Molecular Weight 580.781
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FOROPAFANT FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.CC(C)C1=CC(C(C)C)=C(C2=CSC(=N2)N(CCN(C)C)CC3=CN=CC=C3)C(=C1)C(C)C

InChI

InChIKey=VVMIAYBAROQMMT-WLHGVMLRSA-N
InChI=1S/C28H40N4S.C4H4O4/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22;5-3(6)1-2-4(7)8/h9-11,14-16,18-21H,12-13,17H2,1-8H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula C28H40N4S
Molecular Weight 464.709
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Foropafant is a platelet-activating factor (PAF) antagonist which was developed by Sanofi. It was in clinical development for the treatment of asthma, thrombosis and ulcerative colitis. The development of the drug was discontinued due to lack of efficacy.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P25105
Gene ID: 5724.0
Gene Symbol: PTAFR
Target Organism: Homo sapiens (Human)
57.0 pM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effect of SR 27417 on the binding of [3H]PAF to rabbit and human platelets and human polymorphonuclear leukocytes.
1993 May
Role of tachykinins in castor oil diarrhoea in rats.
1997 Jun
Patents

Patents

Sample Use Guides

In acute asthma study, foropafant was administered orally at 20 mg dosage
Route of Administration: Oral
In Vitro Use Guide
Foropafant displayed marked in vitro inhibition of PAF-induced oxidative burst in guinea pig macrophages (IC50 = 32 nM). Foropafant potently inhibited PAF-induced aggregation of rabbit and human platelets in vitro (IC50 = 0.10 and 0.50 nM, respectively).
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:57:19 GMT 2023
Edited
by admin
on Fri Dec 15 15:57:19 GMT 2023
Record UNII
77229931IM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FOROPAFANT FUMARATE
Common Name English
SR-27417A
Code English
1,2-ETHANEDIAMINE, N1,N1-DIMETHYL-N2-(3-PYRIDINYLMETHYL)-N2-(4-(2,4,6-TRIS(1-METHYLETHYL)PHENYL)-2-THIAZOLYL)-, (2E)-2-BUTENEDIOATE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
9938199
Created by admin on Fri Dec 15 15:57:19 GMT 2023 , Edited by admin on Fri Dec 15 15:57:19 GMT 2023
PRIMARY
FDA UNII
77229931IM
Created by admin on Fri Dec 15 15:57:19 GMT 2023 , Edited by admin on Fri Dec 15 15:57:19 GMT 2023
PRIMARY
CAS
136470-45-6
Created by admin on Fri Dec 15 15:57:19 GMT 2023 , Edited by admin on Fri Dec 15 15:57:19 GMT 2023
PRIMARY
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ACTIVE MOIETY