IOGLUCOMIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H28I3N3O13
Molecular Weight	899.162
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=O)C1=C(I)C(NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C(I)C(NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C1I

InChI

InChIKey=ASFIRRNYUOVVLY-JVOWFEOISA-N

InChI=1S/C20H28I3N3O13/c1-24-18(37)6-7(21)10(25-19(38)16(35)14(33)12(31)4(29)2-27)9(23)11(8(6)22)26-20(39)17(36)15(34)13(32)5(30)3-28/h4-5,12-17,27-36H,2-3H2,1H3,(H,24,37)(H,25,38)(H,26,39)/t4-,5-,12-,13-,14+,15+,16-,17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H28I3N3O13
Molecular Weight	899.162
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7280240 | https://www.ncbi.nlm.nih.gov/pubmed/6388202 | https://www.ncbi.nlm.nih.gov/pubmed/6383860 | https://www.ncbi.nlm.nih.gov/pubmed/6366425

Ioglucomide is triiodoanilide derivative patented by Mallinckrodt, Inc. as nonionic x-ray contrast media for myelography. In preclinical studies the efficacy of ioglucomide and metrizamide were comparable. However, acute toxicity after intravenous injection or installation into cerebrospinal fluid was significantly less for ioglucomide. Also, in contrast to metrizamide, ioglucomide produced no evidence of any type of convulsive activity after subarachnoid administration.

Originator

Approval Year

PubMed

Title	Date	PubMed
Ioglucomide: a new nonionic myelographic agent. Preclinical studies.	1981 Sep	7280240

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:54:45 GMT 2023` Edited by `admin` on `Fri Dec 15 16:54:45 GMT 2023`
Record UNII	771V8M13LT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOGLUCOMIDE

Official Name

English

IOGLUCOMIDE [USAN]

Common Name

English

N,N'-(2,4,6-TRIIODO-5-(METHYLCARBAMOYL)-M-PHENYLENE)BIS(D-GLUCONAMIDE)

Common Name

English

ioglucomide [INN]

Common Name

English

MP-8000

Code

English

D-GLUCONAMIDE, N,N'-(2,4,6-TRIIODO-5-((METHYLAMINO)CARBONYL)-1,3-PHENYLENE)BIS-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28500