THEODRENALINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H21N5O5.ClH
Molecular Weight	411.84
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of THEODRENALINE HYDROCHLORIDE

Structure Search

SMILES

Cl.CN1C2=C(N(CCNCC(O)C3=CC=C(O)C(O)=C3)C=N2)C(=O)N(C)C1=O

InChI

InChIKey=CSKCJAUXLOQTMM-UHFFFAOYSA-N

InChI=1S/C17H21N5O5.ClH/c1-20-15-14(16(26)21(2)17(20)27)22(9-19-15)6-5-18-8-13(25)10-3-4-11(23)12(24)7-10;/h3-4,7,9,13,18,23-25H,5-6,8H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H21N5O5
Molecular Weight	375.3791
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16633089

THEODRENALINE, a theophylline derivative, is a cardiac stimulant. A 20:1 mixture of cafedrine and THEODRENALINE (AKRINOR®) is widely used in Germany for the treatment of hypotensive states during anesthesia and in emergency medicine.

Approval Year

PubMed

Title	Date	PubMed
Akrinor-induced relaxation of pig coronary artery in vitro is transformed into alpha1-adrenoreceptor-mediated contraction by pretreatment with propranolol.	2006 Mar	16633089
Cafedrine/Theodrenaline (20:1) Is an Established Alternative for the Management of Arterial Hypotension in Germany-a Review Based on a Systematic Literature Search.	2017	28270765
A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intra-operative arterial hypotension: the 'HYPOTENS' study design and rationale.	2018 Jun	29415580

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:31:44 GMT 2023` Edited by `admin` on `Sat Dec 16 10:31:44 GMT 2023`
Record UNII	770L7172BR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THEODRENALINE HYDROCHLORIDE

Common Name

English

NSC-293888

Code

English

1H-PURINE-2,6-DIONE, 7-(2-((2-(3,4-DIHYDROXYPHENYL)-2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-, MONOHYDROCHLORIDE

Common Name

English

Theodrenaline hydrochloride [WHO-DD]

Common Name

English

1H-PURINE-2,6-DIONE, 7-(2-((2-(3,4-DIHYDROXYPHENYL)-2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

THEOPHYLLINE, 7-(2-((.BETA.,3,4-TRIHYDROXYPHENETHYL)AMINO)ETHYL)-, MONOHYDROCHLORIDE

Common Name

English

THEOPHYLLINE, 7-(2-((.BETA.,3,4-TRIHYDROXYPHENETHYL)AMINO)ETHYL)-, HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

NSC

293888