THEODRENALINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H21N5O5
Molecular Weight	375.3791
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(N(CCNCC(O)C3=CC=C(O)C(O)=C3)C=N2)C(=O)N(C)C1=O

InChI

InChIKey=WMCMJIGLYZDKRN-UHFFFAOYSA-N

InChI=1S/C17H21N5O5/c1-20-15-14(16(26)21(2)17(20)27)22(9-19-15)6-5-18-8-13(25)10-3-4-11(23)12(24)7-10/h3-4,7,9,13,18,23-25H,5-6,8H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H21N5O5
Molecular Weight	375.3791
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16633089

THEODRENALINE, a theophylline derivative, is a cardiac stimulant. A 20:1 mixture of cafedrine and THEODRENALINE (AKRINOR®) is widely used in Germany for the treatment of hypotensive states during anesthesia and in emergency medicine.

Approval Year

PubMed

Title	Date	PubMed
Akrinor-induced relaxation of pig coronary artery in vitro is transformed into alpha1-adrenoreceptor-mediated contraction by pretreatment with propranolol.	2006 Mar	16633089
Cafedrine/Theodrenaline (20:1) Is an Established Alternative for the Management of Arterial Hypotension in Germany-a Review Based on a Systematic Literature Search.	2017	28270765
A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intra-operative arterial hypotension: the 'HYPOTENS' study design and rationale.	2018 Jun	29415580

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:16:09 UTC 2023` Edited by `admin` on `Sat Dec 16 16:16:09 UTC 2023`
Record UNII	RW8PD99T8G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THEODRENALINE

Official Name

English

Theodrenaline [WHO-DD]

Common Name

English

(±)-7-(2-(2-(3,4-DIHYDROXYPHENYL)-2-HYDROXYETHYLAMINO)ETHYL)THEOPHYLLINE

Systematic Name

English

7-(2-(2-(3,4-DIHYDROXYPHENYL)-2-HYDROXYETHYLAMINO)ETHYL)THEOPHYLLINE

Systematic Name

English

theodrenaline [INN]

Common Name

English

NORADRENALINE THEOPHYLLINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322