| Stereochemistry | RACEMIC |
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 257.2432 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(CO)C(=O)NNCC1=CC=C(O)C(O)=C1O
InChI
InChIKey=BNQDCRGUHNALGH-UHFFFAOYSA-N
InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 257.2432 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AADC) or DOPA decarboxylase inhibitor. Benserazide is only used in conjunction with L-dopa for the treatment of Parkinson's disease under the brand name Madopar in the UK. Madopar HBS (125 mg) is a controlled-release dosage form with 100 mg L-dopa and 25 mg benserazide.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Patients NOT already treated with levodopa:
The usual starting dose is one 50 mg/12.5 mg tablet (50 mg levodopa), three or four times a day.
Your doctor will then increase your dose every 2 to 3 days until they find the right dose for you.
Patients already treated with levodopa:
Your starting dose of Madopar will be one less 100 mg/25 mg tablet than the number of levodopa
500 mg capsules or tablets you take each day. For example if you take four levodopa tablets (2000 mg
levodopa) each day, your doctor will start by giving you three Madopar 100 mg/25 mg tablets daily.
After one week your doctor may then start to increase your dose every 2 to 3 days until they find the
right dose for you.
Patients already treated with a combined levodopa/decarboxylase inhibitor:
The usual starting dose is one 50 mg/12.5 mg tablet (50 mg levodopa), three or four times a day.
Your doctor will then increase your dose every 2 to 3 days until they find the right dose for you.
Route of Administration:
Oral
