OBECABTAGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 15:46:18 GMT 2023` Edited by `admin` on `Sat Dec 16 15:46:18 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD CELL
Fraction Name	T CELLS
Record UNII	760HJB0YRD
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OBECABTAGENE AUTOLEUCEL

Official Name

English

AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O

Common Name

English

OBECABTAGENE AUTOLEUCEL [USAN]

Common Name

English

AUTO1

Code

English

SELF-INACTIVATING LENTIVIRAL VECTOR CONSISTING OF 5' FUSION BETWEEN THE CMV PROMOTER AND HIV LTR, WHERE THE CMV PROMOTER REPLACES THE U3 REGION. PACKAGING SIGNAL (.PSI.), THE REV RESPONSIVE ELEMENT (RRE) AND THE CENTRAL POLYPURINE TRACT (CPPT) ARE RETAIN

Common Name

English

obecabtagene autoleucel [INN]

Common Name

English

AUTO-1

Code

English

Code System Code Type Description

FDA UNII

760HJB0YRD

Created by admin on Sat Dec 16 15:46:18 GMT 2023 , Edited by admin on Sat Dec 16 15:46:18 GMT 2023

PRIMARY

NCI_THESAURUS

C172746

Created by admin on Sat Dec 16 15:46:18 GMT 2023 , Edited by admin on Sat Dec 16 15:46:18 GMT 2023

PRIMARY

INN

11486

Created by admin on Sat Dec 16 15:46:18 GMT 2023 , Edited by admin on Sat Dec 16 15:46:18 GMT 2023

PRIMARY

USAN

JK-262

Created by admin on Sat Dec 16 15:46:18 GMT 2023 , Edited by admin on Sat Dec 16 15:46:18 GMT 2023

PRIMARY

Related Record Type Details


					760HJB0YRD

OBECABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN	OBECABTAGENE AUTOLEUCEL CHIMERIC ANTIGEN RECEPTOR PREPROTEIN	Y96BQ8R24J
VECTOR EXPRESSED PROTEIN	OBECABTAGENE AUTOLEUCEL CHIMERIC ANTIGEN RECEPTOR	Z7MN57NAL9
INSERTED GENE EXPRESSION VECTOR	OBECABTAGENE AUTOLEUCEL LENTIVIRAL VECTOR TRANSGENE INSERT	93SKR9HJ3R