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Description
Curator's Comment: description was created based on several sources, including, http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500014177.pdf, http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=141-079

Eprinomectin is a mixture of two homologues, eprinomectin B1a (90%) and eprinomectin B1b (10%). The drug is indicated for the treatment of gastrointestinal roundworms in cattle. Eprinomectin acts by binding to glutamate-gated chloride ion channels that leads to paralysis and death of the parasite.

CNS Activity

Originator

Merck
238
Curator's Comment: # Merck

Approval Year

1997
189
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
1076
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
EPRINEX

Approved Use

The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms (Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctata (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms (Dictyocaulus viviparus, adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum, H. bovis); lice (Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mange mites (Chorioptes bovis, Sarcoptes scabiei); and horn flies (Haematobia irritans). Controls and protects from reinfection of D. viviparus for 21 days after treatment and H. irritans for 7 days after treatment.

Launch Date

1997
PubMed

PubMed

TitleDatePubMed
Evaluation of a topical formulation of eprinomectin against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions.
2016-06-17
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against larval and adult stages of the cat lungworm, Aelurostrongylus abstrusus.
2014-04-28
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel, against the ticks, Ixodes ricinus and Ixodes scapularis, on cats.
2014-04-28
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and immature stages of the cat flea (Ctenocephalides felis) on cats.
2014-04-28
Preventive efficacy of a topical combination of fipronil--(S)-methoprene--eprinomectin--praziquantel against ear mite (Otodectes cynotis) infestation of cats through a natural infestation model.
2014
Efficacy and safety of topical eprinomectin to control Myocoptes musculinus infestation in mice.
2013-09-12
Characterization of eprinomectin N-deacetylase in rats.
1999-02
Patents

Patents

US20110281920 A1
1
WO2012001083 A2
1
WO2014098623 A1
1

Sample Use Guides

In Vivo Use Guide
One milliliter (5 milligrams per 10 kilograms of body weight (500 microgram per kilogram).
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Mixture
Created
by admin
on Mon Mar 31 18:03:06 GMT 2025
Edited
by admin
on Mon Mar 31 18:03:06 GMT 2025
Record UNII
75KP30FD8O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPRINOMECTIN
GREEN BOOK   INN   MI   USAN   USP   USP-RS  
USAN   INN  
Official Name English
BROADLINE COMPONENT EPRINOMECTIN
Preferred Name English
EPRINOMECTIN [USP-RS]
Common Name English
MK 397
Code English
EPRINEX
Brand Name English
eprinomectin [INN]
Common Name English
AVERMECTIN B1, 4''-(ACETYLAMINO)-4''-DEOXY-, (4''R)-
Common Name English
EPRINOMECTIN [MI]
Common Name English
EPRINOMECTIN [GREEN BOOK]
Common Name English
A MIXTURE OF EPRINOMECTIN COMPONENT B1A AND EPRINOMECTIN COMPONENT B1B
Common Name English
A MIXTURE OF TWO COMPONENTS HAVING A RATIO OF 90% OR MORE OF EPRINOMECTIN COMPONENT B1A AND 10% OR LESS OF EPRINOMECTIN COMPONENT B1B
Common Name English
EPRINOMECTIN [EMA EPAR VETERINARY]
Common Name English
EPRINOMECTIN [USAN]
Common Name English
MK-397
Code English
EPRINOMECTIN [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-VATC QP54AA04
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
WHO-VATC QP54AA54
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
EMA VETERINARY ASSESSMENT REPORTS BROADLINE (AUTHORIZED)
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
CFR 21 CFR 522.814
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CFR 21 CFR 524.814
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
CFR 21 CFR 556.227
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
NCI_THESAURUS C250
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL2106412
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
NCI_THESAURUS
C83694
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
WIKIPEDIA
Eprinomectin
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
RS_ITEM_NUM
1237752
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
CHEBI
82596
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
MERCK INDEX
m4959
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID8037542
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PRIMARY
INN
7371
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PRIMARY
DRUG BANK
DB11405
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PRIMARY
CAS
123997-26-2
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
SMS_ID
300000023854
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
FDA UNII
75KP30FD8O
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
EVMPD
SUB90873
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
RXCUI
1006619
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY RxNorm
ALANWOOD
eprinomectin
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
DAILYMED
75KP30FD8O
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
USAN
GG-62
Created by admin on Mon Mar 31 18:03:06 GMT 2025 , Edited by admin on Mon Mar 31 18:03:06 GMT 2025
PRIMARY
All of the following components must be present:
Structure of EPRINOMECTIN B1B
Structure of EPRINOMECTIN B1A
Related Record Type Details
EPRINOMECTIN
ACTIVE MOIETY
Definition References
NIH
NCATS
PRIVACY NOTICE
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