EPRINOMECTIN

Description
Sources: http://datasheets.scbt.com/sc-359326_mfr.pdf
Curator's Comment: description was created based on several sources, including, http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500014177.pdf, http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=141-079

Eprinomectin is a mixture of two homologues, eprinomectin B1a (90%) and eprinomectin B1b (10%). The drug is indicated for the treatment of gastrointestinal roundworms in cattle. Eprinomectin acts by binding to glutamate-gated chloride ion channels that leads to paralysis and death of the parasite.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate-gated chloride channel 3 Target ID: Glutamate-gated chloride channel Sources: http://www.merial.com.au/SiteCollectionDocuments/ivomec_eprinex_pouron_cattle_msds.pdf	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastrointestinal roundworms infection 2 Sources: http://datasheets.scbt.com/sc-359326_mfr.pdf	Curative		Approved 8429	EPRINEX Approved Use The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms (Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctata (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms (Dictyocaulus viviparus, adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum, H. bovis); lice (Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mange mites (Chorioptes bovis, Sarcoptes scabiei); and horn flies (Haematobia irritans). Controls and protects from reinfection of D. viviparus for 21 days after treatment and H. irritans for 7 days after treatment. Launch Date 1997

PubMed

Title	Date	PubMed
Preventive efficacy of a topical combination of fipronil--(S)-methoprene--eprinomectin--praziquantel against ear mite (Otodectes cynotis) infestation of cats through a natural infestation model.	2014	25148648

Patents

Sample Use Guides

In Vivo Use Guide

One milliliter (5 milligrams per 10 kilograms of body weight (500 microgram per kilogram).

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Mixture Created by `admin` on `Fri Dec 15 15:37:01 GMT 2023` Edited by `admin` on `Fri Dec 15 15:37:01 GMT 2023`
Record UNII	75KP30FD8O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPRINOMECTIN

Official Name

English

EPRINOMECTIN [USP-RS]

Common Name

English

EPRINOMECTIN COMPONENT OF BROADLINE

Brand Name

English

MK 397

Code

English

EPRINEX

Brand Name

English

eprinomectin [INN]

Common Name

English

AVERMECTIN B1, 4''-(ACETYLAMINO)-4''-DEOXY-, (4''R)-

Common Name

English

EPRINOMECTIN [MI]

Common Name

English

EPRINOMECTIN [GREEN BOOK]

Common Name

English

A MIXTURE OF EPRINOMECTIN COMPONENT B1A AND EPRINOMECTIN COMPONENT B1B

Common Name

English

A MIXTURE OF TWO COMPONENTS HAVING A RATIO OF 90% OR MORE OF EPRINOMECTIN COMPONENT B1A AND 10% OR LESS OF EPRINOMECTIN COMPONENT B1B

Common Name

English

EPRINOMECTIN [EMA EPAR VETERINARY]

Common Name

English

EPRINOMECTIN [USAN]

Common Name

English

MK-397

Code

English

BROADLINE COMPONENT EPRINOMECTIN

Brand Name

English

EPRINOMECTIN [USP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QP54AA04