Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H12I2O3 |
Molecular Weight | 518.0843 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=C(C(=O)C2=CC(I)=C(O)C(I)=C2)C3=C(O1)C=CC=C3
InChI
InChIKey=CZCHIEJNWPNBDE-UHFFFAOYSA-N
InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
Molecular Formula | C17H12I2O3 |
Molecular Weight | 518.0843 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/13972645Curator's Comment: description was created based on several sources, including:
http://www.bmj.com/content/2/5413/882.3
http://www.ncbi.nlm.nih.gov/pubmed/12783743
Sources: http://www.ncbi.nlm.nih.gov/pubmed/13972645
Curator's Comment: description was created based on several sources, including:
http://www.bmj.com/content/2/5413/882.3
http://www.ncbi.nlm.nih.gov/pubmed/12783743
Benziodarone is a coronary dilatator drug. Benziodarone in therapeutic dosage has no effect on blood coagulation and does not alter the prothrombin level. Bleeding complications occurred, when benziodarone is given to patients receiving anticoagulant therapy with warfarin sodium. Jaundice might occurred from 8 to 16 weeks after the beginning of the treatment with Benziodarone. Combination of Flecainide with Benziodarone should be avoided or used only with strict monitoring. Benzbromarone is an other benzofuran derivative acting as anuricosuric agent by reducing the proximal tubular reabsorption of uric acid. The hypouricaemic action of benziodarone (Amplivex-Labaz) is prompt. The maximum drop of uricaemia after Amplivex administration (2 tablets/day) occurs during the first three days. The uric acid level declines by as much as 80% of the baseline value. For long-term treatment 1 tablet per day is sufficient, in some instances even 1 tablet twice a week. The tolerance of the preparation is satisfactory.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: proximal tubular reabsorption of uric acid Sources: http://www.ncbi.nlm.nih.gov/pubmed/2257602 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseCoronary vasodilatator Benziodarone has been found experimentally to produce a marked increase in coronary blood flow. |
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Primary | Unknown Approved UseBenziodarone is used for the Gout |
PubMed
Title | Date | PubMed |
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Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. | 2001 Nov |
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Acute uric acid nephropathy by overdosage of benziodarone in a renal transplant recipient. | 2002 |
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A role for uric acid in the progression of renal disease. | 2002 Dec |
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Hyperuricemia causes glomerular hypertrophy in the rat. | 2003 Jan-Feb |
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[Pharmacological interaction between flecainide and benziodarone]. | 2003 Jun |
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Long-term efficacy of hyperuricaemia treatment in renal transplant patients. | 2003 Mar |
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Uric acid: role in cardiovascular disease and effects of losartan. | 2004 Mar |
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[Role of uric acid in hypertension and in the progression of chronic renal disease]. | 2006 Jan-Feb |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/5361006
Benziodarone was found to be a potent inhibitor of the in vitro enzyme-catalyzed conversion of sulfobromophthalein to sulfobromophthalein- glutathione. Approximately 50% inhibition of the enzyme activity was consistently produced in the presence of benziodarone in concentrations of 0.02 - 0.03 mM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:29:58 GMT 2023
by
admin
on
Fri Dec 15 15:29:58 GMT 2023
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Record UNII |
75CL65GTYR
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Record Status |
Validated (UNII)
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WHO-VATC |
QC01DX54
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WHO-ATC |
C01DX04
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WHO-ATC |
C01DX54
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QC01DX04
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NCI_THESAURUS |
C47793
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CHEMBL232201
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75CL65GTYR
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100000086385
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68-90-6
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DTXSID1046134
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DB13277
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200-695-2
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C74127
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m2355
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C058702
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BENZIODARONE
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6237
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SUB05751MIG
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