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Details

Stereochemistry ACHIRAL
Molecular Formula C17H12I2O3
Molecular Weight 518.0843
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENZIODARONE

SMILES

CCC1=C(C(=O)C2=CC(I)=C(O)C(I)=C2)C3=C(O1)C=CC=C3

InChI

InChIKey=CZCHIEJNWPNBDE-UHFFFAOYSA-N
InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

HIDE SMILES / InChI

Molecular Formula C17H12I2O3
Molecular Weight 518.0843
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.bmj.com/content/2/5413/882.3 http://www.ncbi.nlm.nih.gov/pubmed/12783743

Benziodarone is a coronary dilatator drug. Benziodarone in therapeutic dosage has no effect on blood coagulation and does not alter the prothrombin level. Bleeding complications occurred, when benziodarone is given to patients receiving anticoagulant therapy with warfarin sodium. Jaundice might occurred from 8 to 16 weeks after the beginning of the treatment with Benziodarone. Combination of Flecainide with Benziodarone should be avoided or used only with strict monitoring. Benzbromarone is an other benzofuran derivative acting as anuricosuric agent by reducing the proximal tubular reabsorption of uric acid. The hypouricaemic action of benziodarone (Amplivex-Labaz) is prompt. The maximum drop of uricaemia after Amplivex administration (2 tablets/day) occurs during the first three days. The uric acid level declines by as much as 80% of the baseline value. For long-term treatment 1 tablet per day is sufficient, in some instances even 1 tablet twice a week. The tolerance of the preparation is satisfactory.

Originator

Curator's Comment: In scientific publication, Charlier R. described it in July of 1959. http://www.ncbi.nlm.nih.gov/pubmed/13809328

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: proximal tubular reabsorption of uric acid
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Coronary vasodilatator Benziodarone has been found experimentally to produce a marked increase in coronary blood flow.
Primary
Unknown

Approved Use

Benziodarone is used for the Gout
PubMed

PubMed

TitleDatePubMed
A role for uric acid in the progression of renal disease.
2002 Dec
Hyperuricemia causes glomerular hypertrophy in the rat.
2003 Jan-Feb
Patents

Patents

Sample Use Guides

100 mg per day
Route of Administration: Oral
In Vitro Use Guide
Benziodarone was found to be a potent inhibitor of the in vitro enzyme-catalyzed conversion of sulfobromophthalein to sulfobromophthalein- glutathione. Approximately 50% inhibition of the enzyme activity was consistently produced in the presence of benziodarone in concentrations of 0.02 - 0.03 mM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:29:58 GMT 2023
Edited
by admin
on Fri Dec 15 15:29:58 GMT 2023
Record UNII
75CL65GTYR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BENZIODARONE
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
L-2329
Code English
NSC-82133
Code English
L 2329
Code English
BENZIODARONE [MART.]
Common Name English
Benziodarone [WHO-DD]
Common Name English
AMPLIVIX
Brand Name English
BENZIODARONE [MI]
Common Name English
benziodarone [INN]
Common Name English
2-ETHYL-3-BENZOFURANYL 4-HYDROXY-3,5-DIIODOPHENYL KETONE
Systematic Name English
BENZIODARONE [JAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QC01DX54
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
WHO-ATC C01DX04
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
WHO-ATC C01DX54
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
WHO-VATC QC01DX04
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL232201
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
FDA UNII
75CL65GTYR
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
SMS_ID
100000086385
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
INN
984
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
NSC
82133
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
CAS
68-90-6
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
EPA CompTox
DTXSID1046134
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
DRUG BANK
DB13277
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-695-2
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
DRUG CENTRAL
321
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
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NCI_THESAURUS
C74127
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
MERCK INDEX
m2355
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY Merck Index
MESH
C058702
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
WIKIPEDIA
BENZIODARONE
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
PUBCHEM
6237
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
EVMPD
SUB05751MIG
Created by admin on Fri Dec 15 15:29:58 GMT 2023 , Edited by admin on Fri Dec 15 15:29:58 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY