BROMOPRIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H22BrN3O2
Molecular Weight	344.247
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCN(CC)CCNC(=O)C1=CC(Br)=C(N)C=C1OC

InChI

InChIKey=GIYAQDDTCWHPPL-UHFFFAOYSA-N

InChI=1S/C14H22BrN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)

HIDE SMILES / InChI

Molecular Formula	C14H22BrN3O2
Molecular Weight	344.247
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Bromopride is a dopamine D2 receptor blocker. Bromopride exerts is a gastrointestinal prokinetic exploited clinically for the management of motor disorders of the upper gastrointestinal tract, including functional dyspepsia, gastric stasis of various origins and emesis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D2 receptor 297	Antagonist 2,778
cholinesterase activity 5	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dyspepsia 11	Primary		Approved 8,429	Bromopan

PubMed

Show entries

Title	Date	PubMed
Mirtazapine (Remeron) as treatment for non-mechanical vomiting after gastric bypass.	2005 May	15946465
Validated method for determination of bromopride in human plasma by liquid chromatography--electrospray tandem mass spectrometry: application to the bioequivalence study.	2005 Sep	16127659
Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography.	2007 Jan-Feb	17505728
Case-crossover study of Burkholderia cepacia complex bloodstream infection associated with contaminated intravenous bromopride.	2010 May	20205589

Showing 1 to 4 of 4 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Capsules: 40-60 mg/day Oral solution: 40-60 mg/day (adults), 0.5-1 mg/kg (children)

Route of Administration: Oral

In Vitro Use Guide

Bromopride effects on cholinesterase activity in plasma, striatum, duodenum and ileum of adult male rats were measured for drug concentrations ranging from 0.006 to 3.134 microM. Bromopride can inhibit cholinesterase activity in all tissues studied,