| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H24N6O |
| Molecular Weight | 328.4121 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(CCN(CC1)C2=NC=CC=N2)NCC(=O)N3CCC[C@H]3C#N
InChI
InChIKey=JERPHRNGJBSFAP-AWEZNQCLSA-N
InChI=1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
| Molecular Formula | C17H24N6O |
| Molecular Weight | 328.4121 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
K-579 ((S)-1-[4-methyl-1-(2-pyrimidinyl)-4-piperidylamino]acetyl-2-pyrrolidinecarbonitrile) is potent and slower binding dipeptidyl peptidase IV inhibitor which was investigated as an antidiabetic drug. K579 suppressed the blood glucose elevation after an oral glucose tolerance test with the increment of plasma insulin and active forms of Glucagon-like peptide-1 (GLP-1). During repetitive glucose loading using Zucker fatty rats, pretreatment with K579 attenuated the glucose excursion after the second glucose loading as well as the first glucose loading without inducing hypoglycemia.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Zucker fatty rats was treatment with K579 at a doses 0.1, 0.3 or 1mg/kg
Route of Administration:
Oral
GLUTag cells were seeded onto poly-D lysine coated 96 well plates at 8000 cells/well and grown for approximately 48 h. Cells were incubated in assay buffer containing test ligand for1 h at 37 °C. Cells were then washed by four exchanges of fresh buffer, before exposure to buffer containing the diepetidyl peptidase IV inhibitor K-579(100nM)7test compoundfor2hat37 °C. Supernatant was then removed and GLP-1 concentration measured by the 1 concentration measured by the Millipore ELISA kit, as per the manufacturers instructions. Fluorescencewas measured at abs/emof355/460nm using a TecanSafire, and samples compared to a standard curve.
