HUMAN HERPESVIRUS 2

Investigational

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Fri Dec 15 20:30:03 UTC 2023` Edited by `admin` on `Fri Dec 15 20:30:03 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	VIRUS
Organism Family	Herpesviridae
Organism Genus	Simplexvirus
Organism Species	human herpesvirus 2
Author	NONE
Part	WHOLE
Record UNII	74J6DNH49U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HUMAN HERPESVIRUS 2

Common Name

English

HSV-2

Common Name

English

HHV-2

Common Name

English

HERPES SIMPLEX VIRUS-2

Common Name

English

SIMPLEXVIRUS HUMAN HERPESVIRUS 2 WHOLE

Common Name

English

Code System Code Type Description

FDA UNII

74J6DNH49U

Created by admin on Fri Dec 15 20:30:03 UTC 2023 , Edited by admin on Fri Dec 15 20:30:03 UTC 2023

PRIMARY

DAILYMED

74J6DNH49U

Created by admin on Fri Dec 15 20:30:03 UTC 2023 , Edited by admin on Fri Dec 15 20:30:03 UTC 2023

PRIMARY

RXCUI

1318479

Created by admin on Fri Dec 15 20:30:03 UTC 2023 , Edited by admin on Fri Dec 15 20:30:03 UTC 2023

PRIMARY

RxNorm

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VACCINE ANTIGEN->TARGET ORGANISM


					4G4Z4676IS

BUCICLOVIR

INHIBITOR->TARGET ORGANISM

Comments:

The 9-(3,4-dihydroxybut-1-yl)guanine (bucyclovir, 23) with a hydroxyl directly attached to the butyl side chain is very potent against HSV-1 and HSV-2 (IC50=0.4 μM against HSV-1 and 0.9 μM against HSV-2). The stereochemistry of the 3-position of bucyclovir is crucial in determining the antiherpetic activities. While the R configuration is very potent, the S-isomer (24) is essentially inactive against HSV-1 and HSV-2.

Qualification:

IC50

Amount:


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HERPV COMPONENT HSV-2 ICP4, TRANSACTIVATOR (510-544)

VACCINE ANTIGEN->TARGET ORGANISM


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RESIQUIMOD

INHIBITOR->TARGET ORGANISM

Amount:


					912WCW4U5J

HERPV COMPONENT HSV-2 GL, ENVELOPE (185-219)

VACCINE ANTIGEN->TARGET ORGANISM


					I0I636QB3J

HERPV COMPONENT HSV-2 TEGUMENT (93-127)

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					GF6VD960F3

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VACCINE ANTIGEN->TARGET ORGANISM


					QQ29N61F99

HERPV COMPONENT HSV-2 RIBONUCLEOTIDE KINASE (269-303)

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HERPV COMPONENT HSV-2 GB GLYCOPROTEIN (674-708)

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HERPV COMPONENT HSV-2 RNA BINDING, PACKAGING (59-93)

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HERPV COMPONENT HSV-2 GM, GLYCOPROTEIN (418-452)

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					V3TM3K65V6

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HERPV COMPONENT HSV-2 TEGUMENT (640-674)

VACCINE ANTIGEN->TARGET ORGANISM


					0NYZ8B96AS

HERPV COMPONENT HSV-2 RNA BINDING, PACKAGING (5-39)

VACCINE ANTIGEN->TARGET ORGANISM


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PRITELIVIR

INHIBITOR->TARGET ORGANISM

Amount:


					SZ3TJ0XN1R

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VACCINE ANTIGEN->TARGET ORGANISM


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VACCINE ANTIGEN->TARGET ORGANISM


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DENOTIVIR

INHIBITOR->TARGET ORGANISM

Amount:


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HERPV COMPONENT HSV-2 TEGUMENT (148-182)

VACCINE ANTIGEN->TARGET ORGANISM


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HERPV COMPONENT HSV-2 TEGUMENT (145-179)

VACCINE ANTIGEN->TARGET ORGANISM


					359HUE8FJC

PENCICLOVIR

INHIBITOR->TARGET ORGANISM

Comments:

The in vitro activities of penciclovir against HSV-1, HSV-2 and VZV are similar to those of aciclovir, with median IC50 values of 0.4, 1.5 and 4.0 µg/mL, respectively, in MRC-5 cells.

Qualification:

IC50

Amount:

Related Record Type Details


					74J6DNH49U

HUMAN HERPESVIRUS 2

ACTIVE MOIETY