Dalidnetug

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:56:11 GMT 2025` Edited by `admin` on `Wed Apr 02 13:56:11 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	747GJ7X6PG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-2731

Preferred Name

English

Dalidnetug

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens APP (amyloid beta, A4 precursor protein) Abeta], humanized monoclonal antibody

Common Name

English

Immunoglobulin G1, anti-(human N-terminus of ?-amyloid) (human-Mus musculus monoclonal h2731 ?1-chain), disulfide with human-Mus musculus monoclonal h2731 ?-chain, dimer

Common Name

English

dalidnetug [INN]

Common Name

English

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-23*03 (87.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hi

Common Name

English

H2731

Code

English

Code System Code Type Description

FDA UNII

747GJ7X6PG

Created by admin on Wed Apr 02 13:56:11 GMT 2025 , Edited by admin on Wed Apr 02 13:56:11 GMT 2025

PRIMARY

CAS

2991369-43-6

Created by admin on Wed Apr 02 13:56:11 GMT 2025 , Edited by admin on Wed Apr 02 13:56:11 GMT 2025

PRIMARY

INN

13372

Created by admin on Wed Apr 02 13:56:11 GMT 2025 , Edited by admin on Wed Apr 02 13:56:11 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_219
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_222	3_219
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					747GJ7X6PG

Dalidnetug

ACTIVE MOIETY

Comments:

anti-[Homo sapiens APP (amyloid beta, A4 precursor protein)

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL