Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H8N4O3 |
Molecular Weight | 232.1955 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NN=C(\C=C\C2=CC=C(O2)[N+]([O-])=O)C=C1
InChI
InChIKey=XDWLRMBWIWKFNC-HNQUOIGGSA-N
InChI=1S/C10H8N4O3/c11-9-5-2-7(12-13-9)1-3-8-4-6-10(17-8)14(15)16/h1-6H,(H2,11,13)/b3-1+
Molecular Formula | C10H8N4O3 |
Molecular Weight | 232.1955 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
The nitrofuran derivative, nifurprazine, is a topical antibacterial agent used mainly for the treatment of animal diseases. It is a trypanocidal drug. Nifurprazine proved to be the most promising derivative since it was redox-cycled by both T. cruzi LipDH and TR and had pronounced antiparasitic effects in cultures of T. cruzi and Trypanosoma brucei.
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10571254
At concentrations of 100 uM, nifurprazine caused a 72% inhibition of trypanothione reductase (TR) activity. At 10 uM, nifurprazine inhibited parasite growth completely, but was also toxic to the mammalian host cells. Nifurprazine (3 uM) induced a 100% growth inhibition of T. brucei.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:12:11 GMT 2023
by
admin
on
Fri Dec 15 16:12:11 GMT 2023
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Record UNII |
72ZUT1JIEB
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C28394
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6436113
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216-563-2
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1614-20-6
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SUB09275MIG
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2062
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CHEMBL2105219
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72ZUT1JIEB
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m846
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3796
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100000083895
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DTXSID40167141
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C90984
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |