| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H16N2O2S4 |
| Molecular Weight | 324.506 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
S=C(SSC(=S)N1CCOCC1)N2CCOCC2
InChI
InChIKey=KKVYOWPPMNSLCP-UHFFFAOYSA-N
InChI=1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
| Molecular Formula | C10H16N2O2S4 |
| Molecular Weight | 324.506 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Dimorpholinethiuram disulfide is a thiuram derivative which was initially used in the vulcanization of rubber. Later it was shown that dimorpholinethiuram disulfide is an inhibitor of monoglycerol lipase and pyruvate dehydrogenase kinase (PDK). The compound suppresses proliferation of A549 lung cancer cell line in vitro and reduces tumor volume of A549 xenografts in mice.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
The compound was intraperitoneally administered to mice bearing A549 tumor at doses 40 and 80 mg/kg per day. A 21-day continuous treatment of 80 mg/kg dimorpholinethiuram disulfide considerably reduced 67.5% tumor volume compared with the vehicle control.
Route of Administration:
Intraperitoneal