Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H16N2O2S4 |
Molecular Weight | 324.506 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
S=C(SSC(=S)N1CCOCC1)N2CCOCC2
InChI
InChIKey=KKVYOWPPMNSLCP-UHFFFAOYSA-N
InChI=1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
Molecular Formula | C10H16N2O2S4 |
Molecular Weight | 324.506 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Dimorpholinethiuram disulfide is a thiuram derivative which was initially used in the vulcanization of rubber. Later it was shown that dimorpholinethiuram disulfide is an inhibitor of monoglycerol lipase and pyruvate dehydrogenase kinase (PDK). The compound suppresses proliferation of A549 lung cancer cell line in vitro and reduces tumor volume of A549 xenografts in mice.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: O15530 Gene ID: 5170.0 Gene Symbol: PDPK1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26483203 |
49.0 nM [IC50] | ||
Target ID: Q15119 Gene ID: 5164.0 Gene Symbol: PDK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26483203 |
101.0 nM [IC50] | ||
Target ID: Q15120 Gene ID: 5165.0 Gene Symbol: PDK3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26483203 |
313.0 nM [IC50] | ||
Target ID: Q99685 Gene ID: 11343.0 Gene Symbol: MGLL Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26483203 |
6.66 null [pIC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26483203
The compound was intraperitoneally administered to mice bearing A549 tumor at doses 40 and 80 mg/kg per day. A 21-day continuous treatment of 80 mg/kg dimorpholinethiuram disulfide considerably reduced 67.5% tumor volume compared with the vehicle control.
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26483203
A549 cells (obtained from ATCC) were seeded into 96-well plate. After attachment, cells were treated with JX06 and CCK8 assay (Life Technologies) was carried out after incubation for 72 hours. Untreated cells served as the indicator of 100% cell viability.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:14:25 GMT 2023
by
admin
on
Fri Dec 15 19:14:25 GMT 2023
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Record UNII |
72G763P0UO
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Record Status |
Validated (UNII)
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Record Version |
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