TALLIMUSTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C32H38Cl2N10O4
Molecular Weight	697.615
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=C(NC(=O)C2=CC(NC(=O)C3=CC(NC(=O)C4=CC=C(C=C4)N(CCCl)CCCl)=CN3C)=CN2C)C=C1C(=O)NCCC(N)=N

InChI

InChIKey=ARKYUICTMUZVEW-UHFFFAOYSA-N

InChI=1S/C32H38Cl2N10O4/c1-41-18-22(14-25(41)30(46)37-11-8-28(35)36)39-32(48)27-16-23(19-43(27)3)40-31(47)26-15-21(17-42(26)2)38-29(45)20-4-6-24(7-5-20)44(12-9-33)13-10-34/h4-7,14-19H,8-13H2,1-3H3,(H3,35,36)(H,37,46)(H,38,45)(H,39,48)(H,40,47)

HIDE SMILES / InChI

Molecular Formula	C32H38Cl2N10O4
Molecular Weight	697.615
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9516952 | https://adisinsight.springer.com/drugs/800001279

Tallimustine (also known as FCE 24517), an alkylating benzoyl mustard derivative of distamycin A that was studied as an anti-tumor agent. Tallimustine participated in phase I clinical trial in patients with advanced cancer. As a result, the was obtained the recommended Phase II dosage for tallimustine. However, the further development of this drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine.	2001-06	11442489
A phase I and pharmacokinetic study of tallimustine [PNU 152241 (FCE 24517)] in patients with advanced cancer.	1998-01	9516952

Patents

Sample Use Guides

In Vivo Use Guide

Patients with advanced solid tumors received i.v. bolus injections of tallimustine daily for 3 consecutive days. Patients were treated at six dosage levels of 33.3 micrograms/m2/day to 250 micrograms/m2/day for 3 consecutive days, with courses of therapy repeated every 28 days

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:32:03 GMT 2025` Edited by `admin` on `Mon Mar 31 18:32:03 GMT 2025`
Record UNII	71193OXG6S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tallimustine [WHO-DD]

Preferred Name

English

TALLIMUSTINE

Official Name

English

tallimustine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C697