GPI-15427

CN1CCN(CC2=CC=C3OC4=C5C(=CC=C4)C(=O)NN=C5C3=C2)CC1

InChIKey=DZRLVSOGARUEGQ-UHFFFAOYSA-N

InChI=1S/C20H20N4O2/c1-23-7-9-24(10-8-23)12-13-5-6-16-15(11-13)19-18-14(20(25)22-21-19)3-2-4-17(18)26-16/h2-6,11H,7-10,12H2,1H3,(H,22,25)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-{alpha}.	2010-06	20357221
Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model.	2010-04-01	19945439
Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.	2010-03	19672867
Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy.	2009-12	19854869
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.	2008-03-15	17976390
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.	2006-08	16809434
Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock.	2005-12-19	16310767

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:47:23 GMT 2025` Edited by `admin` on `Mon Mar 31 21:47:23 GMT 2025`
Record UNII	70SQZ3QY6L
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

GPI-15427

Common Name

English

(1)BENZOPYRANO(4,3,2-DE)PHTHALAZIN-3(2H)-ONE, 10-((4-METHYL-1-PIPERAZINYL)METHYL)-

Preferred Name

English

10-((4-METHYLPIPERAZIN-1-YL)METHYL)CHROMENO(4,3,2-DE)PHTHALAZIN-3(2H)-ONE

Systematic Name

English

Code System Code Type Description

FDA UNII

70SQZ3QY6L

Created by admin on Mon Mar 31 21:47:23 GMT 2025 , Edited by admin on Mon Mar 31 21:47:23 GMT 2025

PRIMARY

PUBCHEM

11739525

Created by admin on Mon Mar 31 21:47:23 GMT 2025 , Edited by admin on Mon Mar 31 21:47:23 GMT 2025

PRIMARY

CAS

805242-85-7

Created by admin on Mon Mar 31 21:47:23 GMT 2025 , Edited by admin on Mon Mar 31 21:47:23 GMT 2025

PRIMARY

Related Record Type Details


					70SQZ3QY6L

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