CITIOLONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H9NO2S
Molecular Weight	159.206
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1CCSC1=O

InChI

InChIKey=NRFJZTXWLKPZAV-UHFFFAOYSA-N

InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)

HIDE SMILES / InChI

Molecular Formula	C6H9NO2S
Molecular Weight	159.206
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://egypt-drug-index.blogspot.ru/2013/07/reducdyn-citiolonel-cysteine-for-acute.html

Citiolone (N-acetylhomocysteine thiolactone) is an antioxidant drug used in the treatment of liver diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Oxidative Stress 160 Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9827694 \| https://www.ncbi.nlm.nih.gov/pubmed/1864487	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Liver diseases 14 Sources: https://www.ncbi.nlm.nih.gov/pubmed/917333 https://www.ncbi.nlm.nih.gov/pubmed/846658 https://www.ncbi.nlm.nih.gov/pubmed/5137693	Primary		Approved 8429	REDUCDYN Approved Use Reducdyn (Citiolone + L-Cysteine) is used for acute hepatitis, infections and toxic liver diseases, intoxications, side effects of irradiation, Allergic dermatoses, pruritis.

PubMed

Title	Date	PubMed
Organelle specific enzyme markers as indicators of methylmercury neurotoxicity and antidotal efficacy in mice.	2003 Jun	12572686

Patents

Sample Use Guides

In Vivo Use Guide

Reducdyn (Citiolone 50mg/tab. + L-Cysteine 50mg/tab): 3 tablets 3 times daily, to be swallowed whole with some liquid during or immediately after meals.

Route of Administration: Oral

In Vitro Use Guide

Human skin fibroblasts were irradiated following incubation with N-acetyl-homocysteine-thiolactone (citiolone (CIT), 1 mM). Treatments with CIT resulted in a significant rise in glutathione levels compared with control cells, with protection against UVA radiation.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:01:36 GMT 2023` Edited by `admin` on `Fri Dec 15 16:01:36 GMT 2023`
Record UNII	70JKL15MUH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CITIOLONE

Official Name

English

CITIOLONE [MI]

Common Name

English

CITIOLONE [MART.]

Common Name

English

Citiolone [WHO-DD]

Common Name

English

citiolone [INN]

Common Name

English

NSC-22878

Code

English

N-(TETRAHYDRO-2-OXO-3-THIENYL)ACETAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29767