U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H21N5O3S
Molecular Weight 387.456
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of REVOSPIRONE

SMILES

O=C1N(CCCN2CCN(CC2)C3=NC=CC=N3)S(=O)(=O)C4=CC=CC=C14

InChI

InChIKey=MPLTZRTXQLNGED-UHFFFAOYSA-N
InChI=1S/C18H21N5O3S/c24-17-15-5-1-2-6-16(15)27(25,26)23(17)10-4-9-21-11-13-22(14-12-21)18-19-7-3-8-20-18/h1-3,5-8H,4,9-14H2

HIDE SMILES / InChI

Molecular Formula C18H21N5O3S
Molecular Weight 387.456
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Revospirone (BAY VQ 7813) is a pyrimidinylpiperazine derivative that acts as partial agonist at 5-HT1A receptors. Head shakes were reported after administration of revospirone in pigs, and once daily administration for 3-5 days led to a reduction in this head shake response. No behavioral alterations were observed. This compound was never marketed

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P08908
Gene ID: 3350.0
Gene Symbol: HTR1A
Target Organism: Homo sapiens (Human)
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:55:50 GMT 2023
Edited
by admin
on Sat Dec 16 15:55:50 GMT 2023
Record UNII
6X8764TW2J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
REVOSPIRONE
INN  
INN  
Official Name English
revospirone [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28197
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2107024
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
CAS
95847-87-3
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
PUBCHEM
72024
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
WIKIPEDIA
Revospirone
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
EPA CompTox
DTXSID10241982
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
INN
6434
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
NCI_THESAURUS
C76509
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
SMS_ID
100000080556
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
FDA UNII
6X8764TW2J
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
EVMPD
SUB10296MIG
Created by admin on Sat Dec 16 15:55:50 GMT 2023 , Edited by admin on Sat Dec 16 15:55:50 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY