QUIFENADINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H23NO.ClH
Molecular Weight	329.864
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.OC(C1CN2CCC1CC2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=MVCBFPDJWSQMNY-UHFFFAOYSA-N

InChI=1S/C20H23NO.ClH/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21;/h1-10,16,19,22H,11-15H2;1H

HIDE SMILES / InChI

Molecular Formula	C20H23NO
Molecular Weight	293.4027
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://olainfarm.al/wp-content/uploads/2013/02/Fenkarol_Summary-of-Product-Characteristics.pdf | https://www.ncbi.nlm.nih.gov/pubmed/19487925

Quifenadine is an antihistaminic agent. Quifenadine both blocks histamine H1-receptors in the peripheral tissues, and activates enzyme diaminoxidase (histaminase), due to this decreasing the histamine concentration in tissues. It is indicated in cases of pollinosis, acute and chronic urticaria, seasonal rhinitis (hay fever), allergic rhinitis, allergic conjunctivitis, angioneurotic Quinqe’s edema, dermatosis (eczema, neurodermatitis, pruritus etc.), allergic reactions caused by food or medicines. Quifanidine exhibits antiarrhythmic activity in children with frequent premature beats, without significant QT prolongation, or sinus node depression.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

For adults: single dose is 25-50 mg 2-4 times a day. Maximum daily dose is 200 mg. For children older than 12 years - 25 mg 2-3 times a day. The duration of the course of treatment is 10-20 days. If it is necessary, the course of treatment may be repeated.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:31:37 GMT 2023` Edited by `admin` on `Sat Dec 16 08:31:37 GMT 2023`
Record UNII	6WSK4828LL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

QUIFENADINE HYDROCHLORIDE

Common Name

English

3-QUINUCLIDINEMETHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, HYDROCHLORIDE

Systematic Name

English

1-AZABICYCLO(2.2.2)OCTANE-3-METHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

Quifenadine hydrochloride [WHO-DD]

Common Name

English

1-AZABICYCLO(2.2.2)OCTANE-3-METHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, HYDROCHLORIDE

Systematic Name

English

PHENCAROL

Brand Name

English

Code System Code Type Description

FDA UNII

6WSK4828LL